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dc.contributor.authorEbert, JR
dc.contributor.authorRobertson, WB
dc.contributor.authorLloyd, DG
dc.contributor.authorZheng, MH
dc.contributor.authorWood, DJ
dc.contributor.authorAckland, T
dc.date.accessioned2017-05-03T15:56:58Z
dc.date.available2017-05-03T15:56:58Z
dc.date.issued2008
dc.date.modified2011-08-24T07:16:28Z
dc.identifier.issn1063-4584
dc.identifier.doi10.1016/j.joca.2008.03.010
dc.identifier.urihttp://hdl.handle.net/10072/40332
dc.description.abstractObjective To determine the effectiveness of 'accelerated' compared to 'traditional' post-operative load bearing rehabilitation protocols following matrix-induced autologous chondrocyte implantation (MACI). Method A randomized controlled study design was used to investigate clinical, biomechanical and radiographic assessment at 3 months post-surgery in 62 patients following MACI to the medial or lateral femoral condyle. Both rehabilitation interventions sought to protect the implant for an initial period, then incrementally increase load bearing. Under the 'accelerated' protocol, patients reached full weight bearing at 8 weeks post-surgery, compared to 11 weeks for the 'traditional' group. Results Patients in the 'accelerated' group achieved greater 6 min walk distances and daily activity levels as measured by accelerometry (P < 0.05) compared to the 'traditional' group. Furthermore, the 'accelerated' group reported significantly better improvement in knee pain at 12 weeks as indicated by the Knee Injury and Osteoarthritis Outcome Score (P < 0.05), and regardless of the rehabilitation protocol employed, no patient suffered any adverse effect to the implant as assessed by magnetic resonance imaging at 3 months. Comparison of each rehabilitation group with an unaffected control group revealed a significant difference in peak knee adduction and flexion moments for the traditional group (P < 0.05). However, there was no difference for accelerated patients (P > 0.05), which may demonstrate a faster return to knee loading patterns typically observed in unaffected subjects. Conclusion The 'accelerated' load bearing approach that reduced the length of time spent ambulating on crutches resulted in reduced knee pain, improved function, no graft complications and may speed up the recovery of normal gait function. Patient follow-up to at least 24 months would be required to observe longer-term graft outcomes.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherElsevier
dc.publisher.placeUnited Kingdom
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom1131
dc.relation.ispartofpageto1140
dc.relation.ispartofissue10
dc.relation.ispartofjournalOsteoarthritis and Cartilage
dc.relation.ispartofvolume16
dc.rights.retentionY
dc.subject.fieldofresearchBiomedical engineering
dc.subject.fieldofresearchClinical sciences
dc.subject.fieldofresearchSports science and exercise
dc.subject.fieldofresearchcode4003
dc.subject.fieldofresearchcode3202
dc.subject.fieldofresearchcode4207
dc.titleTraditional vs accelerated approaches to post-operative rehabilitation following matrix-induced autologous chondrocyte implantation (MACI): comparison of clinical, biomechanical and radiographic outcomes
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.date.issued2008
gro.hasfulltextNo Full Text
gro.griffith.authorLloyd, David


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