dc.contributor.author | Mahajan, Kedar R | |
dc.contributor.author | Amin, Moein | |
dc.contributor.author | Poturalski, Matthew | |
dc.contributor.author | Lee, Jonathan | |
dc.contributor.author | Herman, Danielle | |
dc.contributor.author | Zheng, Yufan | |
dc.contributor.author | Androjna, Caroline | |
dc.contributor.author | Howell, Mark | |
dc.contributor.author | Fox, Robert J | |
dc.contributor.author | Trapp, Bruce D | |
dc.contributor.author | Jones, Stephen E | |
dc.contributor.author | Nakamura, Kunio | |
dc.contributor.author | Ontaneda, Daniel | |
dc.date.accessioned | 2021-03-29T04:49:34Z | |
dc.date.available | 2021-03-29T04:49:34Z | |
dc.date.issued | 2021 | |
dc.identifier.issn | 1352-4585 | |
dc.identifier.doi | 10.1177/1352458521999651 | |
dc.identifier.uri | http://hdl.handle.net/10072/403474 | |
dc.description.abstract | OBJECTIVE: Describe magnetic resonance imaging (MRI) susceptibility changes in progressive multifocal leukoencephalopathy (PML) and identify neuropathological correlates. METHODS: PML cases and matched controls with primary central nervous system lymphoma (PCNSL) were retrospectively identified. MRI brain at 3 T and 7 T were reviewed. MRI-pathology correlations in fixed brain autopsy tissue were conducted in three subjects with confirmed PML. RESULTS: With PML (n = 26 total, n = 5 multiple sclerosis natalizumab-associated), juxtacortical changes on susceptibility-weighted imaging (SWI) or gradient echo (GRE) sequences were noted in 3/3 cases on 7 T MRI and 14/22 cases (63.6%) on 1.5 T or 8/22 (36.4%) 3 T MRI. Similar findings were only noted in 3/25 (12.0%) of PCNSL patients (odds ratio (OR) 12.83, 95% confidence interval (CI), 2.9-56.7, p < 0.001) on 1.5 or 3 T MRI. On susceptibility sequences available prior to diagnosis of PML, 7 (87.5%) had changes present on average 2.7 ± 1.8 months (mean ± SD) prior to diagnosis. Postmortem 7 T MRI showed SWI changes corresponded to areas of increased iron density along the gray-white matter (GM-WM) junction predominantly in macrophages. CONCLUSION: Susceptibility changes in PML along the GM-WM junction can precede noticeable fluid-attenuated inversion recovery (FLAIR) changes and correlates with iron accumulation in macrophages. | |
dc.description.peerreviewed | Yes | |
dc.language | eng | |
dc.publisher | SAGE Publications | |
dc.relation.ispartofjournal | Multiple Sclerosis Journal | |
dc.subject.fieldofresearch | Clinical sciences | |
dc.subject.fieldofresearch | Neurosciences | |
dc.subject.fieldofresearchcode | 3202 | |
dc.subject.fieldofresearchcode | 3209 | |
dc.subject.keywords | 7 T MRI | |
dc.subject.keywords | PML | |
dc.subject.keywords | gray matter | |
dc.subject.keywords | immunohistochemistry | |
dc.subject.keywords | iron | |
dc.title | Juxtacortical susceptibility changes in progressive multifocal leukoencephalopathy at the gray-white matter junction correlates with iron-enriched macrophages | |
dc.type | Journal article | |
dc.type.description | C1 - Articles | |
dcterms.bibliographicCitation | Mahajan, KR; Amin, M; Poturalski, M; Lee, J; Herman, D; Zheng, Y; Androjna, C; Howell, M; Fox, RJ; Trapp, BD; Jones, SE; Nakamura, K; Ontaneda, D, Juxtacortical susceptibility changes in progressive multifocal leukoencephalopathy at the gray-white matter junction correlates with iron-enriched macrophages, Multiple Sclerosis Journal, 2021 | |
dc.date.updated | 2021-03-29T00:54:35Z | |
gro.description.notepublic | This publication has been entered as an advanced online version in Griffith Research Online. | |
gro.hasfulltext | No Full Text | |
gro.griffith.author | Amin, Moein | |