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dc.contributor.authorMahajan, Kedar R
dc.contributor.authorAmin, Moein
dc.contributor.authorPoturalski, Matthew
dc.contributor.authorLee, Jonathan
dc.contributor.authorHerman, Danielle
dc.contributor.authorZheng, Yufan
dc.contributor.authorAndrojna, Caroline
dc.contributor.authorHowell, Mark
dc.contributor.authorFox, Robert J
dc.contributor.authorTrapp, Bruce D
dc.contributor.authorJones, Stephen E
dc.contributor.authorNakamura, Kunio
dc.contributor.authorOntaneda, Daniel
dc.date.accessioned2021-03-29T04:49:34Z
dc.date.available2021-03-29T04:49:34Z
dc.date.issued2021
dc.identifier.issn1352-4585
dc.identifier.doi10.1177/1352458521999651
dc.identifier.urihttp://hdl.handle.net/10072/403474
dc.description.abstractOBJECTIVE: Describe magnetic resonance imaging (MRI) susceptibility changes in progressive multifocal leukoencephalopathy (PML) and identify neuropathological correlates. METHODS: PML cases and matched controls with primary central nervous system lymphoma (PCNSL) were retrospectively identified. MRI brain at 3 T and 7 T were reviewed. MRI-pathology correlations in fixed brain autopsy tissue were conducted in three subjects with confirmed PML. RESULTS: With PML (n = 26 total, n = 5 multiple sclerosis natalizumab-associated), juxtacortical changes on susceptibility-weighted imaging (SWI) or gradient echo (GRE) sequences were noted in 3/3 cases on 7 T MRI and 14/22 cases (63.6%) on 1.5 T or 8/22 (36.4%) 3 T MRI. Similar findings were only noted in 3/25 (12.0%) of PCNSL patients (odds ratio (OR) 12.83, 95% confidence interval (CI), 2.9-56.7, p < 0.001) on 1.5 or 3 T MRI. On susceptibility sequences available prior to diagnosis of PML, 7 (87.5%) had changes present on average 2.7 ± 1.8 months (mean ± SD) prior to diagnosis. Postmortem 7 T MRI showed SWI changes corresponded to areas of increased iron density along the gray-white matter (GM-WM) junction predominantly in macrophages. CONCLUSION: Susceptibility changes in PML along the GM-WM junction can precede noticeable fluid-attenuated inversion recovery (FLAIR) changes and correlates with iron accumulation in macrophages.
dc.description.peerreviewedYes
dc.languageeng
dc.publisherSAGE Publications
dc.relation.ispartofjournalMultiple Sclerosis Journal
dc.subject.fieldofresearchClinical sciences
dc.subject.fieldofresearchNeurosciences
dc.subject.fieldofresearchcode3202
dc.subject.fieldofresearchcode3209
dc.subject.keywords7 T MRI
dc.subject.keywordsPML
dc.subject.keywordsgray matter
dc.subject.keywordsimmunohistochemistry
dc.subject.keywordsiron
dc.titleJuxtacortical susceptibility changes in progressive multifocal leukoencephalopathy at the gray-white matter junction correlates with iron-enriched macrophages
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationMahajan, KR; Amin, M; Poturalski, M; Lee, J; Herman, D; Zheng, Y; Androjna, C; Howell, M; Fox, RJ; Trapp, BD; Jones, SE; Nakamura, K; Ontaneda, D, Juxtacortical susceptibility changes in progressive multifocal leukoencephalopathy at the gray-white matter junction correlates with iron-enriched macrophages, Multiple Sclerosis Journal, 2021
dc.date.updated2021-03-29T00:54:35Z
gro.description.notepublicThis publication has been entered as an advanced online version in Griffith Research Online.
gro.hasfulltextNo Full Text
gro.griffith.authorAmin, Moein


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