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  • Signalling transduction of O-GlcNAcylation and PI3K/AKT/mTOR-axis in prostate cancer

    Author(s)
    Makwana, V
    Rudrawar, S
    Anoopkumar-Dukie, S
    Griffith University Author(s)
    Anoopkumar-Dukie, Shailendra
    Rudrawar, Santosh
    Makwana, Vivek M.
    Year published
    2021
    Metadata
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    Abstract
    Hexosamine biosynthetic (HBP) and PI3K/AKT/mTOR pathways are found to predominate the proliferation and survival of prostate cancer cells. Both these pathways have their own specific intermediates to propagate the secondary signals in down-stream cascades and besides having their own structured network, also have shared interconnecting branches. These interconnections are either competitive or co-operative in nature depending on the microenvironmental conditions. Specifically, in prostate cancer HBP and mTOR pathways increases the expression and protein level of androgen receptor in order to support cancer cell proliferation, ...
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    Hexosamine biosynthetic (HBP) and PI3K/AKT/mTOR pathways are found to predominate the proliferation and survival of prostate cancer cells. Both these pathways have their own specific intermediates to propagate the secondary signals in down-stream cascades and besides having their own structured network, also have shared interconnecting branches. These interconnections are either competitive or co-operative in nature depending on the microenvironmental conditions. Specifically, in prostate cancer HBP and mTOR pathways increases the expression and protein level of androgen receptor in order to support cancer cell proliferation, advancement and metastasis. Pharmacological inhibition of a single pathway is therefore insufficient to stop disease progression as the cancer cells manage to alter the signalling channel. This is one of the primary reasons for the therapeutic failure in prostate cancer and emergence of chemoresistance. Inhibition of these multiple pathways at their common junctures might prove to be of benefit in men suffering from an advanced disease state. Hence, a thorough understanding of these cellular intersecting points and their significance with respect to signal transduction mechanisms might assist in the rational designing of combinations for effective management of prostate cancer.
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    Journal Title
    Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
    Volume
    1867
    Issue
    7
    DOI
    https://doi.org/10.1016/j.bbadis.2021.166129
    Subject
    Biochemistry and Cell Biology
    Medical Biochemistry and Metabolomics
    Clinical Sciences
    Androgen receptor
    Chemoresistance
    Combinatorial approach
    HBP
    mTOR
    Publication URI
    http://hdl.handle.net/10072/403484
    Collection
    • Journal articles

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