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dc.contributor.authorMakwana, V
dc.contributor.authorRudrawar, S
dc.contributor.authorAnoopkumar-Dukie, S
dc.date.accessioned2021-03-29T05:50:14Z
dc.date.available2021-03-29T05:50:14Z
dc.date.issued2021
dc.identifier.issn0925-4439
dc.identifier.doi10.1016/j.bbadis.2021.166129
dc.identifier.urihttp://hdl.handle.net/10072/403484
dc.description.abstractHexosamine biosynthetic (HBP) and PI3K/AKT/mTOR pathways are found to predominate the proliferation and survival of prostate cancer cells. Both these pathways have their own specific intermediates to propagate the secondary signals in down-stream cascades and besides having their own structured network, also have shared interconnecting branches. These interconnections are either competitive or co-operative in nature depending on the microenvironmental conditions. Specifically, in prostate cancer HBP and mTOR pathways increases the expression and protein level of androgen receptor in order to support cancer cell proliferation, advancement and metastasis. Pharmacological inhibition of a single pathway is therefore insufficient to stop disease progression as the cancer cells manage to alter the signalling channel. This is one of the primary reasons for the therapeutic failure in prostate cancer and emergence of chemoresistance. Inhibition of these multiple pathways at their common junctures might prove to be of benefit in men suffering from an advanced disease state. Hence, a thorough understanding of these cellular intersecting points and their significance with respect to signal transduction mechanisms might assist in the rational designing of combinations for effective management of prostate cancer.
dc.description.peerreviewedYes
dc.languageeng
dc.publisherElsevier BV
dc.relation.ispartofpagefrom166129
dc.relation.ispartofissue7
dc.relation.ispartofjournalBiochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
dc.relation.ispartofvolume1867
dc.subject.fieldofresearchBiochemistry and cell biology
dc.subject.fieldofresearchMedical biochemistry and metabolomics
dc.subject.fieldofresearchClinical sciences
dc.subject.fieldofresearchcode3101
dc.subject.fieldofresearchcode3205
dc.subject.fieldofresearchcode3202
dc.subject.keywordsAndrogen receptor
dc.subject.keywordsChemoresistance
dc.subject.keywordsCombinatorial approach
dc.subject.keywordsHBP
dc.subject.keywordsmTOR
dc.titleSignalling transduction of O-GlcNAcylation and PI3K/AKT/mTOR-axis in prostate cancer
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationMakwana, V; Rudrawar, S; Anoopkumar-Dukie, S, Signalling transduction of O-GlcNAcylation and PI3K/AKT/mTOR-axis in prostate cancer, Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2021, 1867 (7), pp. 166129-
dcterms.dateAccepted2021-03-14
dc.date.updated2021-03-29T01:24:26Z
gro.hasfulltextNo Full Text
gro.griffith.authorAnoopkumar-Dukie, Shailendra
gro.griffith.authorRudrawar, Santosh


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