Show simple item record

dc.contributor.authorBensadoun, Rene-Jean
dc.contributor.authorEpstein, Joel B
dc.contributor.authorNair, Raj G
dc.contributor.authorBarasch, Andrei
dc.contributor.authorRaber-Durlacher, Judith E
dc.contributor.authorMigliorati, Cesar
dc.contributor.authorGenot-Klastersky, Marie-Therese
dc.contributor.authorTreister, Nathaniel
dc.contributor.authorArany, Praveen
dc.contributor.authorLodewijckx, Joy
dc.contributor.authorRobijns, Jolien
dc.date.accessioned2021-03-30T04:37:24Z
dc.date.available2021-03-30T04:37:24Z
dc.date.issued2020
dc.identifier.issn2045-7634
dc.identifier.doi10.1002/cam4.3582
dc.identifier.urihttp://hdl.handle.net/10072/403505
dc.description.abstractWe performed a systematic review of the current literature addressing the safety and efficacy of photobiomodulation therapy (PBMT) in cancer patients. In this systematic review, the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses (PRISMA) guidelines were used. In vitro, in vivo, and clinical studies, which investigated the effect of PBMT on cell proliferation/differentiation, tumor growth, recurrence rate, and/or overall survival were included. The Medline/PubMed, EMBASE, and Scopus databases were searched through April 2020. A total of 67 studies met the inclusion criteria with 43 in vitro, 15 in vivo, and 9 clinical studies identified. In vitro studies investigating the effect of PBMT on a diverse range of cancer cell lines demonstrated conflicting results. This could be due to the differences in used parameters and the frequency of PBM applications. In vivo studies and clinical trials with a follow‐up period demonstrated that PBMT is safe with regards to tumor growth and patient advantage in the prevention and treatment of specific cancer therapy‐related complications. Current human studies, supported by most animal studies, show safety with PBMT using currently recommended clinical parameters, including in Head & Neck cancer (HNC) in the area of PBMT exposure. A significant and growing literature indicates that PBMT is safe and effective, and may even offer a benefit in patient overall survival. Nevertheless, continuing research is indicated to improve understanding and provide further elucidation of remaining questions regarding PBM use in oncology.
dc.description.peerreviewedYes
dc.languageEnglish
dc.publisherWiley
dc.relation.ispartofpagefrom8279
dc.relation.ispartofpageto8300
dc.relation.ispartofissue22
dc.relation.ispartofjournalCancer Medicine
dc.relation.ispartofvolume9
dc.subject.fieldofresearchBiochemistry and cell biology
dc.subject.fieldofresearchOncology and carcinogenesis
dc.subject.fieldofresearchcode3101
dc.subject.fieldofresearchcode3211
dc.subject.keywordsScience & Technology
dc.subject.keywordsLife Sciences & Biomedicine
dc.subject.keywordscancer
dc.subject.keywordsphotobiomodulation
dc.titleSafety and efficacy of photobiomodulation therapy in oncology: A systematic review
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationBensadoun, R-J; Epstein, JB; Nair, RG; Barasch, A; Raber-Durlacher, JE; Migliorati, C; Genot-Klastersky, M-T; Treister, N; Arany, P; Lodewijckx, J; Robijns, J, Safety and efficacy of photobiomodulation therapy in oncology: A systematic review, Cancer Medicine, 2020, 9 (22), pp. 8279-8300
dcterms.dateAccepted2020-10-09
dcterms.licensehttp://creativecommons.org/licenses/by/4.0/
dc.date.updated2021-03-30T03:19:50Z
dc.description.versionVersion of Record (VoR)
gro.rights.copyright© 2020 The Authors. Cancer Medicine published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
gro.hasfulltextFull Text
gro.griffith.authorNair, Raj


Files in this item

This item appears in the following Collection(s)

  • Journal articles
    Contains articles published by Griffith authors in scholarly journals.

Show simple item record