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dc.contributor.authorMcCartney, Danielle
dc.contributor.authorArkell, Thomas R
dc.contributor.authorIrwin, Christopher
dc.contributor.authorMcGregor, Iain S
dc.date.accessioned2021-03-31T04:41:16Z
dc.date.available2021-03-31T04:41:16Z
dc.date.issued2021
dc.identifier.issn0149-7634
dc.identifier.doi10.1016/j.neubiorev.2021.01.003
dc.identifier.urihttp://hdl.handle.net/10072/403530
dc.description.abstractThe increasing legal availability of cannabis has important implications for road safety. This systematic review characterised the acute effects of Δ9-THC on driving performance and driving-related cognitive skills, with a particular focus on the duration of Δ9-THC-induced impairment. Eighty publications and 1534 outcomes were reviewed. Several measures of driving performance and driving-related cognitive skills (e.g. lateral control, tracking, divided attention) demonstrated impairment in meta-analyses of “peak” Δ9-THC effects (p’s<0.05). Multiple meta-regression analyses further found that regular cannabis users experianced less impairment than ‘other’ (mostly occasional) cannabis users (p = 0.003) and that the magnitude of oral (n = 243 effect estimates [EE]) and inhaled (n = 481 EEs) Δ9-THC-induced impairment depended on various factors (dose, post-treatment time interval, the performance domain (skill) assessed) in other cannabis users (p’s<0.05). The latter model predicted that most driving-related cognitive skills would ‘recover’ (Hedges’ g=–0.25) within ∼5-hs (and almost all within ∼7-hs) of inhaling 20 mg of Δ9-THC; oral Δ9-THC-induced impairment may take longer to subside. These results suggest individuals should wait at least 5 -hs following inhaled cannabis use before performing safety-sensitive tasks.
dc.description.peerreviewedYes
dc.languageen
dc.publisherElsevier BV
dc.relation.ispartofpagefrom175
dc.relation.ispartofpageto193
dc.relation.ispartofjournalNeuroscience & Biobehavioral Reviews
dc.relation.ispartofvolume126
dc.subject.fieldofresearchBiomedical and clinical sciences
dc.subject.fieldofresearchPsychology
dc.subject.fieldofresearchcode32
dc.subject.fieldofresearchcode52
dc.titleDetermining the magnitude and duration of acute Δ9-tetrahydrocannabinol (Δ9-THC)-induced driving and cognitive impairment: A systematic and meta-analytic review
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationMcCartney, D; Arkell, TR; Irwin, C; McGregor, IS, Determining the magnitude and duration of acute Δ9-tetrahydrocannabinol (Δ9-THC)-induced driving and cognitive impairment: A systematic and meta-analytic review, Neuroscience & Biobehavioral Reviews, 2021, 126, pp. 175-193
dcterms.licensehttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.date.updated2021-03-24T23:02:44Z
dc.description.versionVersion of Record (VoR)
gro.rights.copyright© 2021 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits unrestricted, non-commercial use, distribution and reproduction in any medium, providing that the work is properly cited.
gro.hasfulltextFull Text
gro.griffith.authorIrwin, Chris G.


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