dc.contributor.author | McCartney, Danielle | |
dc.contributor.author | Arkell, Thomas R | |
dc.contributor.author | Irwin, Christopher | |
dc.contributor.author | McGregor, Iain S | |
dc.date.accessioned | 2021-03-31T04:41:16Z | |
dc.date.available | 2021-03-31T04:41:16Z | |
dc.date.issued | 2021 | |
dc.identifier.issn | 0149-7634 | |
dc.identifier.doi | 10.1016/j.neubiorev.2021.01.003 | |
dc.identifier.uri | http://hdl.handle.net/10072/403530 | |
dc.description.abstract | The increasing legal availability of cannabis has important implications for road safety. This systematic review characterised the acute effects of Δ9-THC on driving performance and driving-related cognitive skills, with a particular focus on the duration of Δ9-THC-induced impairment. Eighty publications and 1534 outcomes were reviewed. Several measures of driving performance and driving-related cognitive skills (e.g. lateral control, tracking, divided attention) demonstrated impairment in meta-analyses of “peak” Δ9-THC effects (p’s<0.05). Multiple meta-regression analyses further found that regular cannabis users experianced less impairment than ‘other’ (mostly occasional) cannabis users (p = 0.003) and that the magnitude of oral (n = 243 effect estimates [EE]) and inhaled (n = 481 EEs) Δ9-THC-induced impairment depended on various factors (dose, post-treatment time interval, the performance domain (skill) assessed) in other cannabis users (p’s<0.05). The latter model predicted that most driving-related cognitive skills would ‘recover’ (Hedges’ g=–0.25) within ∼5-hs (and almost all within ∼7-hs) of inhaling 20 mg of Δ9-THC; oral Δ9-THC-induced impairment may take longer to subside. These results suggest individuals should wait at least 5 -hs following inhaled cannabis use before performing safety-sensitive tasks. | |
dc.description.peerreviewed | Yes | |
dc.language | en | |
dc.publisher | Elsevier BV | |
dc.relation.ispartofpagefrom | 175 | |
dc.relation.ispartofpageto | 193 | |
dc.relation.ispartofjournal | Neuroscience & Biobehavioral Reviews | |
dc.relation.ispartofvolume | 126 | |
dc.subject.fieldofresearch | Biomedical and clinical sciences | |
dc.subject.fieldofresearch | Psychology | |
dc.subject.fieldofresearchcode | 32 | |
dc.subject.fieldofresearchcode | 52 | |
dc.title | Determining the magnitude and duration of acute Δ9-tetrahydrocannabinol (Δ9-THC)-induced driving and cognitive impairment: A systematic and meta-analytic review | |
dc.type | Journal article | |
dc.type.description | C1 - Articles | |
dcterms.bibliographicCitation | McCartney, D; Arkell, TR; Irwin, C; McGregor, IS, Determining the magnitude and duration of acute Δ9-tetrahydrocannabinol (Δ9-THC)-induced driving and cognitive impairment: A systematic and meta-analytic review, Neuroscience & Biobehavioral Reviews, 2021, 126, pp. 175-193 | |
dcterms.license | http://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.date.updated | 2021-03-24T23:02:44Z | |
dc.description.version | Version of Record (VoR) | |
gro.rights.copyright | © 2021 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits unrestricted, non-commercial use, distribution and reproduction in any medium, providing that the work is properly cited. | |
gro.hasfulltext | Full Text | |
gro.griffith.author | Irwin, Chris G. | |