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dc.contributor.authorPaul, Janine
dc.contributor.authorJani, Rati
dc.contributor.authorDavoren, Peter
dc.contributor.authorKnight-Agarwal, Catherine
dc.date.accessioned2021-04-14T03:34:29Z
dc.date.available2021-04-14T03:34:29Z
dc.date.issued2021
dc.identifier.issn1929-0748
dc.identifier.doi10.2196/25085
dc.identifier.urihttp://hdl.handle.net/10072/403730
dc.description.abstractBACKGROUND: Globally, the prevalence of type 1 diabetes mellitus (T1DM) is rising. In 2020, a total of 124,652 Australians had T1DM. Maintaining optimal glycemic control (hemoglobin A1c ≤7.0%, ≤53 mmol/mol) on a standard carbohydrate diet can be a challenge for people living with T1DM. The Diabetes Complications and Control Trial established that macrovascular and microvascular complications could be reduced by improving glycemic control. Recent studies have found that a very low or low carbohydrate diet can improve glycemic control. However, the overall evidence relating to an association between a very low or low carbohydrate diet and glycemic control in people living with T1DM is both limited and mixed. In addition, research has suggested that a reduced quality of life due to anxiety and depression adversely influences glycemic control. Despite a potential link between a very low or low carbohydrate diet and optimal glycemic control, to our knowledge, no research has examined an association between a low carbohydrate diet, quality of life, and glycemic control, making this study unique in its approach. OBJECTIVE: The study aims to develop a validated diabetes-specific quality of life questionnaire for use in Australian adults with T1DM and to determine if an association exists between a low carbohydrate diet, quality of life, and glycemic control in Australian adults living with T1DM. METHODS: This cross-sectional study will be conducted in a tertiary hospital outpatient setting and will consist of 3 phases: phase 1, online Australian diabetes-specific quality of life questionnaire development and piloting (25-30 adults with T1DM); phase 2, questionnaire validation (364 adults with T1DM); and phase 3, a 12-week dietary intervention to determine if an association exists between a low carbohydrate diet, quality of life, and glycemic control in adults with T1DM (16-23 adults with T1DM). The validation of the study-developed Australian diabetes-specific quality of life questionnaire, and changes in hemoglobin A1c and quality of life in adults with T1DM while undertaking a low carbohydrate diet over 12 weeks will be the primary outcomes of this study. RESULTS: Phase 1 of the study is currently open for recruitment and has recruited 12 participants to date. It is anticipated that the first results will be submitted for publication in November 2021. Presently, no results are available. CONCLUSIONS: This study is the first of its kind in that it will be the first to generate a new validated instrument, which could be used in evidence-based practice and research to understand the quality of life of Australian adults with T1DM. Second, the low carbohydrate dietary intervention outcomes could be used to inform clinicians about an alternative approach to assist T1DM adults in improving their quality of life and glycemic control. Finally, this study could warrant the development of an evidence-based low carbohydrate dietary guideline for adults living with T1DM with the potential to have a profound impact on this population.
dc.description.peerreviewedYes
dc.languageeng
dc.publisherJMIR Publications Inc.
dc.relation.ispartofpagefrome25085
dc.relation.ispartofissue3
dc.relation.ispartofjournalJMIR Research Protocols
dc.relation.ispartofvolume10
dc.subject.fieldofresearchClinical sciences
dc.subject.fieldofresearchHealth services and systems
dc.subject.fieldofresearchPublic health
dc.subject.fieldofresearchcode3202
dc.subject.fieldofresearchcode4203
dc.subject.fieldofresearchcode4206
dc.subject.keywordsHbA1c
dc.subject.keywordsadults
dc.subject.keywordsdiet
dc.subject.keywordslow carbohydrate
dc.subject.keywordsquality of life
dc.titleAssociation Between a Low Carbohydrate Diet, Quality of Life, and Glycemic Control in Australian Adults Living With Type 1 Diabetes: Protocol for a Mixed Methods Pilot Study
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationPaul, J; Jani, R; Davoren, P; Knight-Agarwal, C, Association Between a Low Carbohydrate Diet, Quality of Life, and Glycemic Control in Australian Adults Living With Type 1 Diabetes: Protocol for a Mixed Methods Pilot Study, JMIR Research Protocols, 2021, 10 (3), pp. e25085
dcterms.dateAccepted2021-01-21
dcterms.licensehttps://creativecommons.org/licenses/by/4.0/
dc.date.updated2021-04-13T22:23:27Z
dc.description.versionVersion of Record (VoR)
gro.rights.copyright© Janine Paul, Rati Jani, Peter Davoren, Catherine Knight-Agarwal. Originally published in JMIR Research Protocols (http://www.researchprotocols.org), 26.03.2021. This is an open-access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work, first published in JMIR Research Protocols, is properly cited. The complete bibliographic information, a link to the original publication on http://www.researchprotocols.org, as well as this copyright and license information must be included.
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gro.griffith.authorJani, Rati K.


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