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dc.contributor.authorHirunpetcharat, C
dc.contributor.authorStanisic, D
dc.contributor.authorLiu, XQ
dc.contributor.authorVadolas, J
dc.contributor.authorStrugnell, RA
dc.contributor.authorLee, R
dc.contributor.authorMiller, LH
dc.contributor.authorKaslow, DC
dc.contributor.authorGood, MF
dc.date.accessioned2021-04-15T01:50:51Z
dc.date.available2021-04-15T01:50:51Z
dc.date.issued1998
dc.identifier.issn0141-9838en_US
dc.identifier.doi10.1046/j.1365-3024.1998.00161.xen_US
dc.identifier.urihttp://hdl.handle.net/10072/403767
dc.description.abstractVariable protection against malaria blood-stage infection has been demonstrated in mice following parenteral immunization with the highly conserved 19 kD carboxylterminal fragment of the merozoite surface protein-1 (MSP119) using CFA/IFA and other adjuvants. Here we show that intranasal immunization of BALB/C mice with yeast expressed Plasmodium yoelii MSP119 plus a mixture of native and recombinant cholera toxin B subunit, could induce serum MSP119-specific antibodies at titres ranging from 20 000 to 2 560 000. The Ig subclass responses were predominantly G1 and G2b. Intranasal immunization led to protection following challenge (peak parasitaemia < 1%) in mice with the highest MSP119-specific titre (>/= 640 000). In two of the three protected mice, a peak parasitaemia of 0.1%-1% was followed by a boost of the antibody response whereas one of the three protected mice did not boost its antibody response after a peak parasitaemia of 0.02%. In unprotected mice, antibody levels rose, then fell, following the detection of parasites in the peripheral blood. CD4+ T cell-depletion abrogated the ability of the mice to boost their antibody response following challenge. These data demonstrate the potential for intranasal immunization with MSP119 to protect against malaria.en_US
dc.languageEnglishen_US
dc.publisherBlackwell Science Ltden_US
dc.relation.ispartofpagefrom413en_US
dc.relation.ispartofpageto420en_US
dc.relation.ispartofissue9en_US
dc.relation.ispartofjournalParasite Immunologyen_US
dc.relation.ispartofvolume20en_US
dc.subject.fieldofresearchMicrobiologyen_US
dc.subject.fieldofresearchVeterinary Sciencesen_US
dc.subject.fieldofresearchMedical Microbiologyen_US
dc.subject.fieldofresearchcode0605en_US
dc.subject.fieldofresearchcode0707en_US
dc.subject.fieldofresearchcode1108en_US
dc.subject.keywordsScience & Technologyen_US
dc.subject.keywordsLife Sciences & Biomedicineen_US
dc.subject.keywordsImmunologyen_US
dc.subject.keywordsParasitologyen_US
dc.subject.keywordsvaccineen_US
dc.titleIntranasal immunization with yeast-expressed 19 kD carboxyl-terminal fragment of Plasmodium yoelii merozoite surface protein-1 (yMSP1(19)) induces protective immunity to blood stage malaria infection in miceen_US
dc.typeJournal articleen_US
dcterms.bibliographicCitationHirunpetcharat, C; Stanisic, D; Liu, XQ; Vadolas, J; Strugnell, RA; Lee, R; Miller, LH; Kaslow, DC; Good, MF, Intranasal immunization with yeast-expressed 19 kD carboxyl-terminal fragment of Plasmodium yoelii merozoite surface protein-1 (yMSP1(19)) induces protective immunity to blood stage malaria infection in mice, Parasite Immunology, 1998, 20 (9), pp. 413-420en_US
dc.date.updated2021-04-15T01:49:01Z
gro.hasfulltextNo Full Text
gro.griffith.authorStanisic, Danielle


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