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dc.contributor.authorYanatori, Izumi
dc.contributor.authorRichardson, Des R
dc.contributor.authorToyokuni, Shinya
dc.contributor.authorKishi, Fumio
dc.date.accessioned2021-04-16T05:51:24Z
dc.date.available2021-04-16T05:51:24Z
dc.date.issued2019
dc.identifier.issn0003-9861
dc.identifier.doi10.1016/j.abb.2019.108071
dc.identifier.urihttp://hdl.handle.net/10072/403806
dc.description.abstractHeme and iron are essential to almost all forms of life. The strict maintenance of heme and iron homeostasis is essential to prevent cellular toxicity and the existence of systemic and intracellular regulation is fundamental. Cytosolic heme can be catabolized and detoxified by heme oxygenases (HOs). Interestingly, free heme detoxification through HOs results in the production of free ferrous iron, which can be potentially hazardous for cells. Recently, the intracellular iron chaperone, poly (rC)-binding protein 2 (PCBP2), has been identified, which can be involved in accepting iron after heme catabolism as well as intracellular iron transport. In fact, HO1, NADPH-cytochrome P450 reductase, and PCBP2 form a functional unit that integrates the catabolism of heme with the binding and transport of iron by PCBP2. In this review, we provide an overview of our understanding of the iron chaperones and discuss the mechanism how iron chaperones bind iron released during the process of heme degradation.
dc.description.peerreviewedYes
dc.languageEnglish
dc.publisherElsevier
dc.relation.ispartofpagefrom108071
dc.relation.ispartofjournalArchives of Biochemistry and Biophysics
dc.relation.ispartofvolume672
dc.subject.fieldofresearchBiochemistry and cell biology
dc.subject.fieldofresearchcode3101
dc.subject.keywordsScience & Technology
dc.subject.keywordsLife Sciences & Biomedicine
dc.subject.keywordsBiophysics
dc.subject.keywordsHeme oxygenase
dc.subject.keywordsMolecular Biology
dc.titleHow iron is handled in the course of heme catabolism: Integration of heme oxygenase with intracellular iron transport mechanisms mediated by poly (rC)-binding protein-2
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationYanatori, I; Richardson, DR; Toyokuni, S; Kishi, F, How iron is handled in the course of heme catabolism: Integration of heme oxygenase with intracellular iron transport mechanisms mediated by poly (rC)-binding protein-2, Archives of Biochemistry and Biophysics, 2019, 672, pp. 108071
dcterms.dateAccepted2019-08-10
dc.date.updated2021-04-16T03:47:26Z
gro.hasfulltextNo Full Text
gro.griffith.authorRichardson, Des R.


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