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dc.contributor.authorMenezes, Sharleen V
dc.contributor.authorSahni, Sumit
dc.contributor.authorKovacevic, Zaklina
dc.contributor.authorRichardson, Des R
dc.date.accessioned2021-04-22T04:36:05Z
dc.date.available2021-04-22T04:36:05Z
dc.date.issued2017
dc.identifier.issn0021-9258en_US
dc.identifier.doi10.1074/jbc.R117.776393en_US
dc.identifier.urihttp://hdl.handle.net/10072/403899
dc.description.abstractThe iron-regulated metastasis suppressor N-myc downstream-regulated gene 1 (NDRG1) has been shown to inhibit numerous oncogenic signaling pathways in cancer cells. Recent findings have demonstrated that NDRG1 inhibits the ErbB family of receptors, which function as key inducers of carcinogenesis. NDRG1 attenuates ErbB signaling by inhibiting formation of epidermal growth factor receptor (EGFR)/human epidermal growth factor receptor 2 (HER2) and HER2/HER3 heterodimers and by down-regulating EGFR via a mechanism involving its degradation. Understanding the complex interplay between NDRG1, iron, and ErbB signaling is vital for identifying novel, more effective targets for cancer therapy.en_US
dc.description.peerreviewedYesen_US
dc.languageEnglishen_US
dc.publisherElsevieren_US
dc.relation.ispartofpagefrom12772en_US
dc.relation.ispartofpageto12782en_US
dc.relation.ispartofissue31en_US
dc.relation.ispartofjournalJournal of Biological Chemistryen_US
dc.relation.ispartofvolume292en_US
dc.subject.fieldofresearchChemical Sciencesen_US
dc.subject.fieldofresearchBiological Sciencesen_US
dc.subject.fieldofresearchMedical and Health Sciencesen_US
dc.subject.fieldofresearchcode03en_US
dc.subject.fieldofresearchcode06en_US
dc.subject.fieldofresearchcode11en_US
dc.subject.keywordsScience & Technologyen_US
dc.subject.keywordsLife Sciences & Biomedicineen_US
dc.subject.keywordsBiochemistry & Molecular Biologyen_US
dc.subject.keywordscancer therapyen_US
dc.subject.keywordscell signalingen_US
dc.titleInterplay of the iron-regulated metastasis suppressor NDRG1 with epidermal growth factor receptor (EGFR) and oncogenic signalingen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Articlesen_US
dcterms.bibliographicCitationMenezes, SV; Sahni, S; Kovacevic, Z; Richardson, DR, Interplay of the iron-regulated metastasis suppressor NDRG1 with epidermal growth factor receptor (EGFR) and oncogenic signaling, Journal of Biological Chemistry, 2017, 292 (31), pp. 12772-12782en_US
dcterms.licensehttp://creativecommons.org/licenses/by/4.0/en_US
dc.date.updated2021-04-22T04:15:53Z
dc.description.versionVersion of Record (VoR)en_US
gro.rights.copyright© 2017 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology. This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 International License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.en_US
gro.hasfulltextFull Text
gro.griffith.authorRichardson, Des R.


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