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dc.contributor.authorGamell, Cristina
dc.contributor.authorBandilovska, Ivona
dc.contributor.authorGulati, Twishi
dc.contributor.authorKogan, Arielle
dc.contributor.authorLim, Syer Choon
dc.contributor.authorKovacevic, Zaklina
dc.contributor.authorTakano, Elena A
dc.contributor.authorTimpone, Clelia
dc.contributor.authorAgupitan, Arjelle D
dc.contributor.authorLitchfield, Cassandra
dc.contributor.authorBlandino, Giovanni
dc.contributor.authorHorvath, Lisa G
dc.contributor.authorFox, Stephen B
dc.contributor.authorRichardson, Des R
dc.contributor.authoret al.
dc.date.accessioned2021-04-23T04:45:27Z
dc.date.available2021-04-23T04:45:27Z
dc.date.issued2019
dc.identifier.issn2589-0042en_US
dc.identifier.doi10.1016/j.isci.2019.10.065en_US
dc.identifier.urihttp://hdl.handle.net/10072/403963
dc.description.abstractAlthough primary prostate cancer is largely curable, progression to metastatic disease is associated with very poor prognosis. E6AP is an E3 ubiquitin ligase and a transcriptional co-factor involved in normal prostate development. E6AP drives prostate cancer when overexpressed. Our study exposed a role for E6AP in the promotion of metastatic phenotype in prostate cells. We revealed that elevated levels of E6AP in primary prostate cancer correlate with regional metastasis and demonstrated that E6AP promotes acquisition of mesenchymal features, migration potential, and ability for anchorage-independent growth. We identified the metastasis suppressor NDRG1 as a target of E6AP and showed it is key in E6AP induction of mesenchymal phenotype. We showed that treatment of prostate cancer cells with pharmacological agents upregulated NDRG1 expression suppressed E6AP-induced cell migration. We propose that the E6AP-NDRG1 axis is an attractive therapeutic target for the treatment of E6AP-driven metastatic prostate cancer. Biological Sciences; Cell Biology; Canceren_US
dc.description.peerreviewedYesen_US
dc.languageEnglishen_US
dc.publisherCell Pressen_US
dc.relation.ispartofpagefrom1en_US
dc.relation.ispartofpageto15en_US
dc.relation.ispartofjournaliScienceen_US
dc.relation.ispartofvolume22en_US
dc.subject.keywordsScience & Technologyen_US
dc.subject.keywordsMultidisciplinary Sciencesen_US
dc.subject.keywordsScience & Technology - Other Topicsen_US
dc.subject.keywordsSELECTIVE ANTITUMOR-ACTIVITYen_US
dc.subject.keywordsDOWNSTREAM REGULATED GENE-1en_US
dc.titleE6AP Promotes a Metastatic Phenotype in Prostate Canceren_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Articlesen_US
dcterms.bibliographicCitationGamell, C; Bandilovska, I; Gulati, T; Kogan, A; Lim, SC; Kovacevic, Z; Takano, EA; Timpone, C; Agupitan, AD; Litchfield, C; Blandino, G; Horvath, LG; Fox, SB; Richardson, DR; et al., E6AP Promotes a Metastatic Phenotype in Prostate Cancer, iScience, 2019, 22, pp. 1-15en_US
dcterms.dateAccepted2019-10-29
dcterms.licensehttps://creativecommons.org/licenses/by/4.0/en_US
dc.date.updated2021-04-23T04:42:11Z
dc.description.versionVersion of Record (VoR)en_US
gro.rights.copyright© The Author(s) 2019. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License, which permits unrestricted, non-commercial use, distribution and reproduction in any medium, providing that the work is properly cited.en_US
gro.hasfulltextFull Text
gro.griffith.authorRichardson, Des R.


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