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dc.contributor.authorZjalić, M
dc.contributor.authorMustapić, M
dc.contributor.authorGlumac, Z
dc.contributor.authorProloščić, I
dc.contributor.authorBlažetić, S
dc.contributor.authorVuković, A
dc.contributor.authorMasud, M
dc.contributor.authorBillah, M
dc.contributor.authorKhan, A
dc.contributor.authorŠegota, S
dc.contributor.authorHossain, MSA
dc.contributor.authorHeffer, M
dc.date.accessioned2021-04-27T01:58:36Z
dc.date.available2021-04-27T01:58:36Z
dc.date.issued2021
dc.identifier.issn2215-0161en_US
dc.identifier.doi10.1016/j.mex.2021.101312en_US
dc.identifier.urihttp://hdl.handle.net/10072/403971
dc.description.abstractIron nanoparticles are used as a targeted drug delivery system. The nanocarrier itself can be genotoxic, trigger oxidative stress or cell death. Therefore, we developed an AC/DC magnetic syringe for injecting, stimulating drug release and safe removing of the nanocarrier. Alongside we optimized the method for nanoparticles’ drug release kinetics and testing cytotoxicity in vitro. • This paper presents detailed instructions for construction of AC/DC magnetic syringe device for stimulated drug release, injection and ejection of magnetic nanoparticles; nanoparticles preparation; adsorbing methylene blue on nanoparticles; determination of drug release kinetics from nanocarriers on the example of methylene blue • Gomori´s Prussian blue reaction for differentiated SH-SY5Y human neuroblastoma cell line; MTT viability assay optimized for differentiated SH-SY5Y human neuroblastoma cell line and antioxidant enzymes activities assay and lipid peroxidation methods are optimized for cell analyses cell cultivation for nanoparticles cytotoxicity testing in vitro. • Those protocols are the first step toward further testing the effect of nanoparticles in vivo, on brain tissue.en_US
dc.description.peerreviewedYesen_US
dc.languageenen_US
dc.publisherElsevier BVen_US
dc.relation.ispartofpagefrom101312en_US
dc.relation.ispartofjournalMethodsXen_US
dc.relation.ispartofvolume8en_US
dc.subject.fieldofresearchMaterials Engineeringen_US
dc.subject.fieldofresearchcode0912en_US
dc.titleConstruction of AC/DC magnetic syringe device for stimulated drug release, injection and ejection of nanocarriers and testing cytotoxicity in vitroen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Articlesen_US
dcterms.bibliographicCitationZjalić, M; Mustapić, M; Glumac, Z; Prološčić, I; Blažetić, S; Vuković, A; Masud, M; Billah, M; Khan, A; Šegota, S; Hossain, MSA; Heffer, M, Construction of AC/DC magnetic syringe device for stimulated drug release, injection and ejection of nanocarriers and testing cytotoxicity in vitro, MethodsX, 2021, 8, pp. 101312en_US
dcterms.licensehttps://creativecommons.org/licenses/by/4.0/en_US
dc.date.updated2021-04-26T21:51:09Z
dc.description.versionVersion of Record (VoR)en_US
gro.rights.copyright© 2021 Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.en_US
gro.hasfulltextFull Text
gro.griffith.authorMasud, Mostafa Kamal K.


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