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dc.contributor.authorNguyen, AQ
dc.contributor.authorVu, HP
dc.contributor.authorNguyen, LN
dc.contributor.authorWang, Q
dc.contributor.authorDjordjevic, SP
dc.contributor.authorDonner, E
dc.contributor.authorYin, H
dc.contributor.authorNghiem, LD
dc.date.accessioned2021-04-29T00:50:47Z
dc.date.available2021-04-29T00:50:47Z
dc.date.issued2021
dc.identifier.issn0048-9697en_US
dc.identifier.doi10.1016/j.scitotenv.2021.146964en_US
dc.identifier.urihttp://hdl.handle.net/10072/404006
dc.description.abstractAntimicrobial resistance (AMR) is a growing threat to human and animal health. Progress in molecular biology has revealed new and significant challenges for AMR mitigation given the immense diversity of antibiotic resistance genes (ARGs), the complexity of ARG transfer, and the broad range of omnipresent factors contributing to AMR. Municipal, hospital and abattoir wastewater are collected and treated in wastewater treatment plants (WWTPs), where the presence of diverse selection pressures together with a highly concentrated consortium of pathogenic/commensal microbes create favourable conditions for the transfer of ARGs and proliferation of antibiotic resistant bacteria (ARB). The rapid emergence of antibiotic resistant pathogens of clinical and veterinary significance over the past 80 years has re-defined the role of WWTPs as a focal point in the fight against AMR. By reviewing the occurrence of ARGs in wastewater and sludge and the current technologies used to quantify ARGs and identify ARB, this paper provides a research roadmap to address existing challenges in AMR control via wastewater treatment. Wastewater treatment is a double-edged sword that can act as either a pathway for AMR spread or as a barrier to reduce the environmental release of anthropogenic AMR. State of the art ARB identification technologies, such as metagenomic sequencing and fluorescence-activated cell sorting, have enriched ARG/ARB databases, unveiled keystone species in AMR networks, and improved the resolution of AMR dissemination models. Data and information provided in this review highlight significant knowledge gaps. These include inconsistencies in ARG reporting units, lack of ARG/ARB monitoring surrogates, lack of a standardised protocol for determining ARG removal via wastewater treatments, and the inability to support appropriate risk assessment. This is due to a lack of standard monitoring targets and agreed threshold values, and paucity of information on the ARG-pathogen host relationship and risk management. These research gaps need to be addressed and research findings need to be transformed into practical guidance for WWTP operators to enable effective progress towards mitigating the evolution and spread of AMR.en_US
dc.description.peerreviewedYesen_US
dc.languageenen_US
dc.publisherElsevier BVen_US
dc.relation.ispartofpagefrom146964en_US
dc.relation.ispartofjournalScience of the Total Environmenten_US
dc.relation.ispartofvolume783en_US
dc.subject.fieldofresearchCivil Engineeringen_US
dc.subject.fieldofresearchMicrobiologyen_US
dc.subject.fieldofresearchPublic Health and Health Servicesen_US
dc.subject.fieldofresearchcode0905en_US
dc.subject.fieldofresearchcode0605en_US
dc.subject.fieldofresearchcode1117en_US
dc.titleMonitoring antibiotic resistance genes in wastewater treatment: Current strategies and future challengesen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Articlesen_US
dcterms.bibliographicCitationNguyen, AQ; Vu, HP; Nguyen, LN; Wang, Q; Djordjevic, SP; Donner, E; Yin, H; Nghiem, LD, Monitoring antibiotic resistance genes in wastewater treatment: Current strategies and future challenges, Science of the Total Environment, 2021, 783, pp. 146964en_US
dc.date.updated2021-04-29T00:24:44Z
gro.hasfulltextNo Full Text
gro.griffith.authorWang, Qilin


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