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  • Anthocyanin Supplementation Alleviates Antithrombotic Risk by Inhibiting Platelet Activity in Humans

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    Author(s)
    Colson, Natalie
    Gaiz, Almottesembellah Abdalruhman
    Kundur, Avinash R
    Nikbakht, Elham
    Shibeeb, Sapha
    Singh, Indu
    Vugic, Lada
    Griffith University Author(s)
    Kundur, Avinash R.
    Singh, Indu
    Vugic, Lada
    Colson, Natalie J.
    Year published
    2022
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    Abstract
    Background: Platelet hyperactivity has a crucial role in initiating vascular thrombosis and subsequent cardiovascular disease (CVD). Objective: This study aimed to assess the effect of anthocyanins (AC) on platelet aggregation and activation and lipid profile. Study Design: A total of 26 healthy participants consumed 320 mg of AC/day in the form of Medox® capsules for 28 days. Setting: This study was conducted in the laboratories of the School of Medical Sciences, Griffith University, Gold Coast, Australia. Participants: A total of 26 randomly recruited healthy 25- to 75-year-old participants completed this study. Primary ...
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    Background: Platelet hyperactivity has a crucial role in initiating vascular thrombosis and subsequent cardiovascular disease (CVD). Objective: This study aimed to assess the effect of anthocyanins (AC) on platelet aggregation and activation and lipid profile. Study Design: A total of 26 healthy participants consumed 320 mg of AC/day in the form of Medox® capsules for 28 days. Setting: This study was conducted in the laboratories of the School of Medical Sciences, Griffith University, Gold Coast, Australia. Participants: A total of 26 randomly recruited healthy 25- to 75-year-old participants completed this study. Primary Outcome Measures: Fasting blood samples were collected pre- and post-the intervention period to perform platelet activation studies by measuring platelet surface marker expression of CD41a and P-selectin, and platelet-monocyte aggregates in adenosine diphosphate (ADP) stimulated platelets. Platelet aggregation studies were performed by stimulating platelets with various agonists such as ADP, collagen and arachidonic acid. Full blood examination, coagulation and biochemistry profile analyses were also performed pre- and post-intervention. Flow cytometric analysis showed a significant effect of AC on the expression of P-selectin as measured by the platelet surface expression of CD62p. Results: There was a significant reduction of ADP-stimulated platelet aggregation. Hematologic analysis showed a significant reduction of mean platelet volume, mean cell hemoglobin, and mean cell hemoglobin concentration. Coagulation analysis demonstrated significant attenuation of fibrinogen level in the blood. Conclusion: This study showed inhibition of platelet activity, platelet aggregation and mean platelet volume (MPV). These results suggest that AC has a positive impact on attenuating platelet activity, which might minimize thrombotic risk.
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    Journal Title
    Alternative Therapies In Health And Medicine
    Volume
    28
    Issue
    2
    Publisher URI
    http://www.alternative-therapies.com/index.cfm/fuseaction/archives.main
    Copyright Statement
    © 2022 InnoVision Health Media. This article is protected by copyright. To share or copy this article, please visit https://www.copyright.com. Use ISSN# 1078-6791. To subscribe, visit http://www.alternative-therapies.com.
    Subject
    Clinical sciences
    Traditional, complementary and integrative medicine
    Publication URI
    http://hdl.handle.net/10072/404036
    Collection
    • Journal articles

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