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dc.contributor.authorBasha, Maram T
dc.contributor.authorBordini, Jeane
dc.contributor.authorRichardson, Des R
dc.contributor.authorMartinez, Manuel
dc.contributor.authorBernhardt, Paul V
dc.date.accessioned2021-04-30T00:50:50Z
dc.date.available2021-04-30T00:50:50Z
dc.date.issued2016
dc.identifier.issn0162-0134en_US
dc.identifier.doi10.1016/j.jinorgbio.2015.12.004en_US
dc.identifier.urihttp://hdl.handle.net/10072/404048
dc.description.abstractThe oxidation of human oxyhemoglobin (HbO2) to methemoglobin (metHb) is an undesirable side effect identified in some promising thiosemicarbazone anti-cancer drugs. This is attributable to oxidation reactions driven by FeIII complexes of these drugs formed in vivo. In this work the FeIII complexes of selected 2-benzoylpyridine thiosemicarbazones (HBpT), 2-acetylpyridine thiosemicarbazones (HApT), and the clinically trialled thiosemicarbazone, Triapine® (3-amino-2-pyridinecarboxaldehyde thiosemicarbazone, H3-AP), have been studied. This was achieved by time-resolved UV–Visible absorption spectroscopy and the sequential oxidation of the α- and β-chains of HbO2 at distinctly different rates has been identified. A key structural element, namely a terminal –NH2 group on the thiosemicarbazone moiety, was found to be an important common feature of the most active HbO2 oxidising complexes that were investigated. Therefore, these studies indicate that an unsubstituted –NH2 moiety at the terminus of the thiosemicarbazone group should be avoided in the design of future compounds from this class.en_US
dc.description.peerreviewedYesen_US
dc.languageEnglishen_US
dc.publisherElsevieren_US
dc.relation.ispartofpagefrom326en_US
dc.relation.ispartofpageto333en_US
dc.relation.ispartofjournalJournal of Inorganic Biochemistryen_US
dc.relation.ispartofvolume162en_US
dc.subject.fieldofresearchInorganic Chemistryen_US
dc.subject.fieldofresearchTheoretical and Computational Chemistryen_US
dc.subject.fieldofresearchOther Chemical Sciencesen_US
dc.subject.fieldofresearchcode0302en_US
dc.subject.fieldofresearchcode0307en_US
dc.subject.fieldofresearchcode0399en_US
dc.subject.keywordsScience & Technologyen_US
dc.subject.keywordsLife Sciences & Biomedicineen_US
dc.subject.keywordsPhysical Sciencesen_US
dc.subject.keywordsBiochemistry & Molecular Biologyen_US
dc.subject.keywordsChemistry, Inorganic & Nuclearen_US
dc.titleKinetico-mechanistic studies on methemoglobin generation by biologically active thiosemicarbazone iron(III) complexesen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Articlesen_US
dcterms.bibliographicCitationBasha, MT; Bordini, J; Richardson, DR; Martinez, M; Bernhardt, PV, Kinetico-mechanistic studies on methemoglobin generation by biologically active thiosemicarbazone iron(III) complexes, Journal of Inorganic Biochemistry, 2016, 162, pp. 326-333en_US
dcterms.dateAccepted2015-12-08
dcterms.licensehttps://creativecommons.org/licenses/by-nc-nd/4.0/en_US
dc.date.updated2021-04-30T00:47:50Z
dc.description.versionAccepted Manuscript (AM)en_US
gro.rights.copyright© 2016 Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International Licence (http://creativecommons.org/licenses/by-nc-nd/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, providing that the work is properly cited.en_US
gro.hasfulltextFull Text
gro.griffith.authorRichardson, Des R.


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