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dc.contributor.authorBasha, Maram T
dc.contributor.authorBordini, Jeane
dc.contributor.authorRichardson, Des R
dc.contributor.authorMartinez, Manuel
dc.contributor.authorBernhardt, Paul V
dc.date.accessioned2021-04-30T00:50:50Z
dc.date.available2021-04-30T00:50:50Z
dc.date.issued2016
dc.identifier.issn0162-0134
dc.identifier.doi10.1016/j.jinorgbio.2015.12.004
dc.identifier.urihttp://hdl.handle.net/10072/404048
dc.description.abstractThe oxidation of human oxyhemoglobin (HbO2) to methemoglobin (metHb) is an undesirable side effect identified in some promising thiosemicarbazone anti-cancer drugs. This is attributable to oxidation reactions driven by FeIII complexes of these drugs formed in vivo. In this work the FeIII complexes of selected 2-benzoylpyridine thiosemicarbazones (HBpT), 2-acetylpyridine thiosemicarbazones (HApT), and the clinically trialled thiosemicarbazone, Triapine® (3-amino-2-pyridinecarboxaldehyde thiosemicarbazone, H3-AP), have been studied. This was achieved by time-resolved UV–Visible absorption spectroscopy and the sequential oxidation of the α- and β-chains of HbO2 at distinctly different rates has been identified. A key structural element, namely a terminal –NH2 group on the thiosemicarbazone moiety, was found to be an important common feature of the most active HbO2 oxidising complexes that were investigated. Therefore, these studies indicate that an unsubstituted –NH2 moiety at the terminus of the thiosemicarbazone group should be avoided in the design of future compounds from this class.
dc.description.peerreviewedYes
dc.languageEnglish
dc.publisherElsevier
dc.relation.ispartofpagefrom326
dc.relation.ispartofpageto333
dc.relation.ispartofjournalJournal of Inorganic Biochemistry
dc.relation.ispartofvolume162
dc.subject.fieldofresearchInorganic chemistry
dc.subject.fieldofresearchTheoretical and computational chemistry
dc.subject.fieldofresearchOther chemical sciences
dc.subject.fieldofresearchcode3402
dc.subject.fieldofresearchcode3407
dc.subject.fieldofresearchcode3499
dc.subject.keywordsScience & Technology
dc.subject.keywordsLife Sciences & Biomedicine
dc.subject.keywordsPhysical Sciences
dc.subject.keywordsBiochemistry & Molecular Biology
dc.subject.keywordsChemistry, Inorganic & Nuclear
dc.titleKinetico-mechanistic studies on methemoglobin generation by biologically active thiosemicarbazone iron(III) complexes
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationBasha, MT; Bordini, J; Richardson, DR; Martinez, M; Bernhardt, PV, Kinetico-mechanistic studies on methemoglobin generation by biologically active thiosemicarbazone iron(III) complexes, Journal of Inorganic Biochemistry, 2016, 162, pp. 326-333
dcterms.dateAccepted2015-12-08
dcterms.licensehttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.date.updated2021-04-30T00:47:50Z
dc.description.versionAccepted Manuscript (AM)
gro.rights.copyright© 2016 Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International Licence (http://creativecommons.org/licenses/by-nc-nd/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, providing that the work is properly cited.
gro.hasfulltextFull Text
gro.griffith.authorRichardson, Des R.


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