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dc.contributor.authorSingh, OP
dc.contributor.authorSyn, G
dc.contributor.authorNylén, S
dc.contributor.authorEngwerda, C
dc.contributor.authorSacks, D
dc.contributor.authorWilson, ME
dc.contributor.authorKumar, R
dc.contributor.authorChakravarty, J
dc.contributor.authorSundar, S
dc.contributor.authorBlackwell, JM
dc.contributor.authorFakiola, M
dc.date.accessioned2021-05-04T05:03:56Z
dc.date.available2021-05-04T05:03:56Z
dc.date.issued2021
dc.identifier.issn0022-1899
dc.identifier.doi10.1093/infdis/jiaa381
dc.identifier.urihttp://hdl.handle.net/10072/404133
dc.description.abstractVisceral leishmaniasis (VL; Leishmania donovani) cases produce interferon-γ and tumor necrosis factor in response to soluble leishmanial antigen (SLA) in whole-blood assays. Using transcriptional profiling, we demonstrate the impact of interleukin-10 (IL-10), a cytokine implicated in VL, on this response. SLA stimulation identified 28 differentially expressed genes (DEGs), 17/28 in a single network with TNF as hub. SLA plus anti-IL-10 produced 454 DEGs, 292 in a single network with TNF, IFNG, NFKBIA, IL6, and IL1B as hubs in concert with a remarkable chemokine/cytokine storm. Our data demonstrate the singular effect of IL-10 as a potent immune modulator in VL.
dc.description.peerreviewedYes
dc.languageeng
dc.publisherOxford University Press (OUP)
dc.relation.ispartofpagefrom517
dc.relation.ispartofpageto521
dc.relation.ispartofissue3
dc.relation.ispartofjournalThe Journal of infectious diseases
dc.relation.ispartofvolume223
dc.subject.fieldofresearchBiological Sciences
dc.subject.fieldofresearchMedical and Health Sciences
dc.subject.fieldofresearchcode06
dc.subject.fieldofresearchcode11
dc.subject.keywordsRNA expression
dc.subject.keywordsanti
dc.subject.keywordscytokine storm
dc.subject.keywordsinterleukin-10
dc.subject.keywordssoluble leishmania antigen
dc.titleAnti-Interleukin-10 Unleashes Transcriptional Response to Leishmanial Antigens in Visceral Leishmaniasis Patients
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationSingh, OP; Syn, G; Nylén, S; Engwerda, C; Sacks, D; Wilson, ME; Kumar, R; Chakravarty, J; Sundar, S; Blackwell, JM; Fakiola, M, Anti-Interleukin-10 Unleashes Transcriptional Response to Leishmanial Antigens in Visceral Leishmaniasis Patients, The Journal of infectious diseases, 2021, 223 (3), pp. 517-521
dcterms.dateAccepted2020-06-25
dc.date.updated2021-05-04T04:55:55Z
dc.description.versionAccepted Manuscript (AM)
gro.rights.copyright© 2021 The Author. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. This is a pre-copy-editing, author-produced PDF of an article accepted for publication in Journal of Infectious Diseases following peer review. The definitive publisher-authenticated version,Anti-Interleukin-10 Unleashes Transcriptional Response to Leishmanial Antigens in Visceral Leishmaniasis Patients, The Journal of infectious diseases, 2021, 223 (3), pp. 517-521 is available online at: https://doi.org/10.1016/j.cell.2021.03.026.
gro.hasfulltextFull Text
gro.griffith.authorEngwerda, Christian R.


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