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dc.contributor.authorSingh, Bhawana
dc.contributor.authorBhushan Chauhan, Shashi
dc.contributor.authorKumar, Rajiv
dc.contributor.authorSingh, Siddharth Sankar
dc.contributor.authorNg, Susanna
dc.contributor.authorAmante, Fiona
dc.contributor.authorde Labastida Rivera, Fabian
dc.contributor.authorSingh, Om Prakash
dc.contributor.authorRai, Madhukar
dc.contributor.authorNylen, Susanne
dc.contributor.authorSundar, Shyam
dc.contributor.authorEngwerda, Christian
dc.date.accessioned2021-05-04T05:16:14Z
dc.date.available2021-05-04T05:16:14Z
dc.date.issued2019
dc.identifier.issn0141-9838
dc.identifier.doi10.1111/pim.12669
dc.identifier.urihttp://hdl.handle.net/10072/404134
dc.description.abstractCD8+ T‐cell function is compromised in chronic diseases such as visceral leishmaniasis (VL). However, little is known about the changes in gene expression that cause CD8+ T‐cell dysfunction during VL. We used targeted transcriptional profiling of peripheral blood CD8+ T cells from VL patients pre‐ and post‐anti‐parasitic drug treatment, and compared them with the same cell population from healthy endemic controls to assess their activation, differentiation and functional status during disease. We found a predominance of downregulated immune genes in CD8+ T cells from VL patients. However, genes encoding several notable immune checkpoint molecules, including LAG‐3, TIM‐3 and CTLA‐4, cytolytic molecules, such as granzymes A, B and H and perforin, as well as SOCS3, STAT1, JAK2 and JAK3 cytokine signalling genes were found to be increasingly expressed by VL patient CD8+ T cells. Additional studies confirmed increased expression of the inhibitory receptors LAG3 and TIM3 on VL patient CD8+ T cells, thereby identifying these molecules as potential targets to improve antigen‐specific CD8+ T‐cell responses during disease.
dc.description.peerreviewedYes
dc.languageEnglish
dc.publisherWiley
dc.relation.ispartofissue11
dc.relation.ispartofjournalParasite Immunology
dc.relation.ispartofvolume41
dc.subject.fieldofresearchMicrobiology
dc.subject.fieldofresearchVeterinary Sciences
dc.subject.fieldofresearchMedical Microbiology
dc.subject.fieldofresearchcode0605
dc.subject.fieldofresearchcode0707
dc.subject.fieldofresearchcode1108
dc.subject.keywordsScience & Technology
dc.subject.keywordsLife Sciences & Biomedicine
dc.subject.keywordsImmunology
dc.subject.keywordsParasitology
dc.subject.keywordscoinhibitory receptors
dc.titleA molecular signature for CD8(+) T cells from visceral leishmaniasis patients
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationSingh, B; Bhushan Chauhan, S; Kumar, R; Singh, SS; Ng, S; Amante, F; de Labastida Rivera, F; Singh, OP; Rai, M; Nylen, S; Sundar, S; Engwerda, C, A molecular signature for CD8(+) T cells from visceral leishmaniasis patients, Parasite Immunology, 2019, 41 (11)
dcterms.dateAccepted2019-08-31
dc.date.updated2021-05-04T05:15:20Z
gro.hasfulltextNo Full Text
gro.griffith.authorEngwerda, Christian R.


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