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dc.contributor.authorNdukwe, HC
dc.contributor.authorNishtala, PS
dc.date.accessioned2021-05-04T23:30:35Z
dc.date.available2021-05-04T23:30:35Z
dc.date.issued2016
dc.identifier.issn0268-1315
dc.identifier.doi10.1097/YIC.0000000000000112
dc.identifier.urihttp://hdl.handle.net/10072/404146
dc.description.abstractTo examine and characterize overall donepezil and concomitant utilization with β-blockers, yearly, in older New Zealanders. Deidentified data from the Pharmaceutical claims database and the National Minimum Dataset were obtained for 2011 to 2013 from the Ministry of Health. Population-level data were extracted for donepezil and β-blockers utilization, measured by defined daily dose (DDD) per thousand older people per day (TOPD). Donepezil utilization increased from 5.2 to 8.2 DDD/TOPD between 2011 and 2013. In 2011, the number of prevalent users was 4634, the mean age was 79.4±6.6 years and 57.5% were women. Highest use by age for donepezil was in those aged 85 years or older (2.3 DDD/TOPD), followed by those aged 80-84 years (2.2 DDD/TOPD). The mean utilization volumes were significantly lower for donepezil 5 mg (Student t-test= 9.86; P< 0.05) and 10 mg (10.90; P<0.05) in the 65- to 69-year age group compared with the 80- to 84-year age group, whereas the proportion of concomitant utilization of donepezil with β-blockers decreased (17.9% to 5.1%). Donepezil utilization in DDD/TOPD increased by three-fifths between 2011 and 2013. Prescribers appear to be aware of the potential risk of bradycardia with the concomitant use of donepezil and β-blockers.
dc.description.peerreviewedYes
dc.languageeng
dc.publisherOvid Technologies (Wolters Kluwer Health)
dc.relation.ispartofpagefrom170
dc.relation.ispartofpageto175
dc.relation.ispartofissue3
dc.relation.ispartofjournalInternational Clinical Psychopharmacology
dc.relation.ispartofvolume31
dc.subject.fieldofresearchPharmacology and Pharmaceutical Sciences
dc.subject.fieldofresearchPsychology
dc.subject.fieldofresearchcode1115
dc.subject.fieldofresearchcode1701
dc.titleTemporal trends for donepezil utilization among older people
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationNdukwe, HC; Nishtala, PS, Temporal trends for donepezil utilization among older people, International Clinical Psychopharmacology, 2016, 31 (3), pp. 170-175
dc.date.updated2021-05-04T23:29:29Z
gro.hasfulltextNo Full Text
gro.griffith.authorNdukwe, Henry C.


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