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dc.contributor.authorNdukwe, HC
dc.contributor.authorNishtala, PS
dc.date.accessioned2021-05-04T23:30:35Z
dc.date.available2021-05-04T23:30:35Z
dc.date.issued2016
dc.identifier.issn0268-1315
dc.identifier.doi10.1097/YIC.0000000000000112
dc.identifier.urihttp://hdl.handle.net/10072/404146
dc.description.abstractTo examine and characterize overall donepezil and concomitant utilization with β-blockers, yearly, in older New Zealanders. Deidentified data from the Pharmaceutical claims database and the National Minimum Dataset were obtained for 2011 to 2013 from the Ministry of Health. Population-level data were extracted for donepezil and β-blockers utilization, measured by defined daily dose (DDD) per thousand older people per day (TOPD). Donepezil utilization increased from 5.2 to 8.2 DDD/TOPD between 2011 and 2013. In 2011, the number of prevalent users was 4634, the mean age was 79.4±6.6 years and 57.5% were women. Highest use by age for donepezil was in those aged 85 years or older (2.3 DDD/TOPD), followed by those aged 80-84 years (2.2 DDD/TOPD). The mean utilization volumes were significantly lower for donepezil 5 mg (Student t-test= 9.86; P< 0.05) and 10 mg (10.90; P<0.05) in the 65- to 69-year age group compared with the 80- to 84-year age group, whereas the proportion of concomitant utilization of donepezil with β-blockers decreased (17.9% to 5.1%). Donepezil utilization in DDD/TOPD increased by three-fifths between 2011 and 2013. Prescribers appear to be aware of the potential risk of bradycardia with the concomitant use of donepezil and β-blockers.
dc.description.peerreviewedYes
dc.languageeng
dc.publisherOvid Technologies (Wolters Kluwer Health)
dc.relation.ispartofpagefrom170
dc.relation.ispartofpageto175
dc.relation.ispartofissue3
dc.relation.ispartofjournalInternational Clinical Psychopharmacology
dc.relation.ispartofvolume31
dc.subject.fieldofresearchPharmacology and pharmaceutical sciences
dc.subject.fieldofresearchcode3214
dc.titleTemporal trends for donepezil utilization among older people
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationNdukwe, HC; Nishtala, PS, Temporal trends for donepezil utilization among older people, International Clinical Psychopharmacology, 2016, 31 (3), pp. 170-175
dc.date.updated2021-05-04T23:29:29Z
gro.hasfulltextNo Full Text
gro.griffith.authorNdukwe, Henry C.


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