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dc.contributor.authorHan, Jianying
dc.contributor.authorJiang, Lan
dc.contributor.authorZhang, Lixin
dc.contributor.authorQuinn, Ronald J
dc.contributor.authorLiu, Xueting
dc.contributor.authorFeng, Yunjiang
dc.date.accessioned2021-05-12T00:05:06Z
dc.date.available2021-05-12T00:05:06Z
dc.date.issued2021
dc.identifier.issn0175-7598
dc.identifier.doi10.1007/s00253-021-11312-z
dc.identifier.urihttp://hdl.handle.net/10072/404191
dc.description.abstractMeroterpenoids are a class of terpenoid-containing hybrid natural products with impressive structural architectures and remarkable pharmacological activities. Remarkable advances in enzymology and synthetic biology have greatly contributed to the elucidation of the molecular basis for their biosynthesis. Here, we review structurally unique meroterpenoids catalyzed by novel enzymes and unusual enzymatic reactions over the period of last 5 years. We also discuss recent progress on the biomimetic synthesis of chrome meroterpenoids and synthetic biology-driven biomanufacturing of tropolone sesquiterpenoids, merochlorins, and plant-derived meroterpenoid cannabinoids. In particular, we focus on the novel enzymes involved in the biosynthesis of polyketide-terpenoids, nonribosomal peptide-terpenoids, terpenoid alkaloids, and meroterpenoid with unique structures. The biological activities of these meroterpenoids are also discussed. The information reviewed here might provide useful clues and lay the foundation for developing new meroterpenoid-derived drugs.
dc.description.peerreviewedYes
dc.languageeng
dc.publisherSpringer Science and Business Media LLC
dc.relation.ispartofjournalApplied Microbiology and Biotechnology
dc.subject.fieldofresearchBiological Sciences
dc.subject.fieldofresearchcode06
dc.subject.keywordsBiomanufacturing
dc.subject.keywordsBiomimetic synthesis
dc.subject.keywordsMeroterpenoids
dc.subject.keywordsSynthetic biology
dc.titlePeculiarities of meroterpenoids and their bioproduction
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationHan, J; Jiang, L; Zhang, L; Quinn, RJ; Liu, X; Feng, Y, Peculiarities of meroterpenoids and their bioproduction, Applied Microbiology and Biotechnology, 2021
dcterms.dateAccepted2021-04-20
dc.date.updated2021-05-05T22:59:11Z
dc.description.versionAccepted Manuscript (AM)
gro.description.notepublicThis publication has been entered as an advanced online version in Griffith Research Online.
gro.rights.copyright© 2021 Springer Berlin / Heidelberg. This is an electronic version of an article published in Applied Microbiology and Biotechnology, 2021. Applied Microbiology and Biotechnology is available online at: http://link.springer.com/ with the open URL of your article.
gro.hasfulltextFull Text
gro.griffith.authorHan, Jianying
gro.griffith.authorFeng, Yun J.
gro.griffith.authorQuinn, Ronald J.


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