Show simple item record

dc.contributor.authorMatar, Caline G
dc.contributor.authorAnthony, Neil R
dc.contributor.authorO'Flaherty, Brigid M
dc.contributor.authorJacobs, Nathan T
dc.contributor.authorPriyamvada, Lalita
dc.contributor.authorEngwerda, Christian R
dc.contributor.authorSpeck, Samuel H
dc.contributor.authorLamb, Tracey J
dc.date.accessioned2021-05-06T04:39:07Z
dc.date.available2021-05-06T04:39:07Z
dc.date.issued2015
dc.identifier.issn1553-7366en_US
dc.identifier.doi10.1371/journal.ppat.1004858en_US
dc.identifier.urihttp://hdl.handle.net/10072/404199
dc.description.abstractImmunity to non-cerebral severe malaria is estimated to occur within 1-2 infections in areas of endemic transmission for Plasmodium falciparum. Yet, nearly 20% of infected children die annually as a result of severe malaria. Multiple risk factors are postulated to exacerbate malarial disease, one being co-infections with other pathogens. Children living in Sub-Saharan Africa are seropositive for Epstein Barr Virus (EBV) by the age of 6 months. This timing overlaps with the waning of protective maternal antibodies and susceptibility to primary Plasmodium infection. However, the impact of acute EBV infection on the generation of anti-malarial immunity is unknown. Using well established mouse models of infection, we show here that acute, but not latent murine gammaherpesvirus 68 (MHV68) infection suppresses the anti-malarial humoral response to a secondary malaria infection. Importantly, this resulted in the transformation of a non-lethal P. yoelii XNL infection into a lethal one; an outcome that is correlated with a defect in the maintenance of germinal center B cells and T follicular helper (Tfh) cells in the spleen. Furthermore, we have identified the MHV68 M2 protein as an important virus encoded protein that can: (i) suppress anti-MHV68 humoral responses during acute MHV68 infection; and (ii) plays a critical role in the observed suppression of anti-malarial humoral responses in the setting of co-infection. Notably, co-infection with an M2-null mutant MHV68 eliminates lethality of P. yoelii XNL. Collectively, our data demonstrates that an acute gammaherpesvirus infection can negatively impact the development of an anti-malarial immune response. This suggests that acute infection with EBV should be investigated as a risk factor for non-cerebral severe malaria in young children living in areas endemic for Plasmodium transmission.en_US
dc.description.peerreviewedYesen_US
dc.languageEnglishen_US
dc.publisherPublic Library Scienceen_US
dc.relation.ispartofpagefrom1en_US
dc.relation.ispartofpageto23en_US
dc.relation.ispartofissue5en_US
dc.relation.ispartofjournalPLOS Pathogensen_US
dc.relation.ispartofvolume11en_US
dc.subject.fieldofresearchMicrobiologyen_US
dc.subject.fieldofresearchImmunologyen_US
dc.subject.fieldofresearchMedical Microbiologyen_US
dc.subject.fieldofresearchcode0605en_US
dc.subject.fieldofresearchcode1107en_US
dc.subject.fieldofresearchcode1108en_US
dc.subject.keywordsScience & Technologyen_US
dc.subject.keywordsLife Sciences & Biomedicineen_US
dc.subject.keywordsMicrobiologyen_US
dc.subject.keywordsParasitologyen_US
dc.subject.keywordsVirologyen_US
dc.titleGammaherpesvirus Co-infection with Malaria Suppresses Anti-parasitic Humoral Immunityen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Articlesen_US
dcterms.bibliographicCitationMatar, CG; Anthony, NR; O'Flaherty, BM; Jacobs, NT; Priyamvada, L; Engwerda, CR; Speck, SH; Lamb, TJ, Gammaherpesvirus Co-infection with Malaria Suppresses Anti-parasitic Humoral Immunity, PLOS PATHOGENS, 2015, 11 (5)en_US
dcterms.dateAccepted2015-04-06
dcterms.licensehttps://creativecommons.org/licenses/by/4.0/en_US
dc.date.updated2021-05-06T04:34:04Z
dc.description.versionVersion of Record (VoR)en_US
gro.rights.copyright© 2015 Matar et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.en_US
gro.hasfulltextFull Text
gro.griffith.authorEngwerda, Christian R.


Files in this item

This item appears in the following Collection(s)

  • Journal articles
    Contains articles published by Griffith authors in scholarly journals.

Show simple item record