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  • Lower temperatures reduce type I interferon activity and promote alphaviral arthritis

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    Author(s)
    Prow, Natalie A
    Tang, Bing
    Gardner, Joy
    Le, Thuy T
    Taylor, Adam
    Poo, Yee Suan
    Nakayama, Eri
    Hirata, Thiago DC
    Nakaya, Helder I
    Slonchak, Andrii
    Mukhopadhyay, Pamela
    Mahalingam, Suresh
    Schroder, Wayne A
    Klimstra, William
    Suhrbier, Andreas
    Griffith University Author(s)
    Mahalingam, Suresh
    Taylor, Adam
    Schroder, Wayne
    Year published
    2017
    Metadata
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    Abstract
    Chikungunya virus (CHIKV) belongs to a group of mosquito-borne alphaviruses associated with acute and chronic arthropathy, with peripheral and limb joints most commonly affected. Using a mouse model of CHIKV infection and arthritic disease, we show that CHIKV replication and the ensuing foot arthropathy were dramatically reduced when mice were housed at 30°C, rather than the conventional 22°C. The effect was not associated with a detectable fever, but was dependent on type I interferon responses. Bioinformatics analyses of RNA-Seq data after injection of poly(I:C)/jetPEI suggested the unfolded protein response and certain ...
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    Chikungunya virus (CHIKV) belongs to a group of mosquito-borne alphaviruses associated with acute and chronic arthropathy, with peripheral and limb joints most commonly affected. Using a mouse model of CHIKV infection and arthritic disease, we show that CHIKV replication and the ensuing foot arthropathy were dramatically reduced when mice were housed at 30°C, rather than the conventional 22°C. The effect was not associated with a detectable fever, but was dependent on type I interferon responses. Bioinformatics analyses of RNA-Seq data after injection of poly(I:C)/jetPEI suggested the unfolded protein response and certain type I interferon responses are promoted when feet are slightly warmer. The ambient temperature thus appears able profoundly to effect anti-viral activity in the periphery, with clear consequences for alphaviral replication and the ensuing arthropathy. These observations may provide an explanation for why alphaviral arthropathies are largely restricted to joints of the limbs and the extremities.
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    Journal Title
    PLoS Pathogens
    Volume
    13
    Issue
    12
    DOI
    https://doi.org/10.1371/journal.ppat.1006788
    Copyright Statement
    © 2017 Prow et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
    Subject
    Microbiology
    Microbiology not elsewhere classified
    Immunology
    Medical microbiology
    Science & Technology
    Life Sciences & Biomedicine
    Microbiology
    Parasitology
    Virology
    Publication URI
    http://hdl.handle.net/10072/404201
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    • Journal articles

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