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  • Sirtuins, a potential target in Traumatic Brain Injury and relevant experimental models

    Author(s)
    Ranadive, N
    Arora, D
    Nampoothiri, M
    Mudgal, J
    Griffith University Author(s)
    Arora, Devinder S.
    Year published
    2021
    Metadata
    Show full item record
    Abstract
    Traumatic brain injury (TBI) can simply be defined as a violent external injury to the head causing brain dysfunction. The primary injury occurs immediately on impact whereas the secondary injury begins minutes to months after impact. TBI affects a vast majority of population worldwide yet, there isn't any therapeutic intervention available. Sirtuins (SIRTs) are important regulator proteins found in humans. In several neurodegenerative diseases, SIRTs have proven its neuroprotective actions. Owing to the pathophysiological similarities in these diseases and TBI, SIRTs may serve as a potential target for therapeutic intervention ...
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    Traumatic brain injury (TBI) can simply be defined as a violent external injury to the head causing brain dysfunction. The primary injury occurs immediately on impact whereas the secondary injury begins minutes to months after impact. TBI affects a vast majority of population worldwide yet, there isn't any therapeutic intervention available. Sirtuins (SIRTs) are important regulator proteins found in humans. In several neurodegenerative diseases, SIRTs have proven its neuroprotective actions. Owing to the pathophysiological similarities in these diseases and TBI, SIRTs may serve as a potential target for therapeutic intervention in TBI. This review aims to describe the relevance of SIRTs as a potential pharmacological target in TBI. Also, the experimental animal model of TBI explored to understand the role of SIRTs in TBI have been discussed.
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    Journal Title
    Brain Research Bulletin
    Volume
    171
    DOI
    https://doi.org/10.1016/j.brainresbull.2021.03.016
    Subject
    Neurosciences
    Psychology
    Cognitive and computational psychology
    Glial cell activation
    Neuroinflammation
    Sirtuins
    Traumatic brain injury
    Publication URI
    http://hdl.handle.net/10072/404217
    Collection
    • Journal articles

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