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  • The Dietary Inflammatory Index and Human Health: An Umbrella Review of Meta-Analyses of Observational Studies

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    Accepted Manuscript (AM)
    Author(s)
    Marx, Wolfgang
    Veronese, Nicola
    Kelly, Jaimon T
    Smith, Lee
    Hockey, Meghan
    Collins, Sam
    Trakman, Gina L
    Hoare, Erin
    Teasdale, Scott B
    Wade, Alexandra
    Lane, Melissa
    Aslam, Hajara
    Davis, Jessica A
    O'Neil, Adrienne
    et al.
    Griffith University Author(s)
    Kelly, Jaimon
    Year published
    2021
    Metadata
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    Abstract
    Numerous observational studies have investigated the role of the Dietary Inflammatory Index (DII®) in chronic disease risk. The aims of this umbrella review and integrated meta-analyses were to systematically synthesize the observational evidence reporting on the associations between the DII and health outcomes based on meta-analyses, and to assess the quality and strength of the evidence for each associated outcome. This umbrella review with integrated meta-analyses investigated the association between the DII and a range of health outcomes based on meta-analyses of observational data. A credibility assessment was conducted ...
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    Numerous observational studies have investigated the role of the Dietary Inflammatory Index (DII®) in chronic disease risk. The aims of this umbrella review and integrated meta-analyses were to systematically synthesize the observational evidence reporting on the associations between the DII and health outcomes based on meta-analyses, and to assess the quality and strength of the evidence for each associated outcome. This umbrella review with integrated meta-analyses investigated the association between the DII and a range of health outcomes based on meta-analyses of observational data. A credibility assessment was conducted for each outcome using the following criteria: statistical heterogeneity, 95% prediction intervals, evidence for small-study effect and/or excess significance bias, as well as effect sizes and P values using calculated random effects meta-analyses. In total, 15 meta-analyses reporting on 38 chronic disease-related outcomes were included, incorporating a total population of 4,360,111 subjects. Outcomes (n = 38) were examined through various study designs including case-control (n = 8), cross-sectional (n = 5), prospective (n = 5), and combination (n = 20) study designs. Adherence to a pro-inflammatory dietary pattern had a significant positive association with 27 (71%) of the included health outcomes (P value < 0.05). Using the credibility assessment, Class I (Convincing) evidence was identified for myocardial infarction only, Class II (Highly suggestive) evidence was identified for increased risk of all-cause mortality, overall risk of incident cancer, and risk of incident site-specific cancers (colorectal, pancreatic, respiratory, and oral cancers) with increasing (more pro-inflammatory) DII score. Most outcomes (n = 31) presented Class III (Suggestive) or lower evidence (Weak or No association). Pro-inflammatory dietary patterns were nominally associated with an increased risk of many chronic disease outcomes. However, the strength of evidence for most outcomes was limited. Further prospective studies are required to improve the precision of the effect size.
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    Journal Title
    Advances in Nutrition
    DOI
    https://doi.org/10.1093/advances/nmab037
    Copyright Statement
    © The Author(s) 2021. Published by Oxford University Press on behalf of the American Society for Nutrition. This is a pre-copy-editing, author-produced PDF of an article accepted for publication in Advances in Nutrition following peer review. The definitive publisher-authenticated version The Dietary Inflammatory Index and Human Health: An Umbrella Review of Meta-Analyses of Observational Studies, Advances in Nutrition, 2021 is available online at: https://doi.org/10.1093/advances/nmab037.
    Note
    This publication has been entered in Griffith Research Online as an advanced online version.
    Subject
    Nutrition and dietetics
    cancer
    cardiovascular disease
    diet
    dietary inflammatory index
    inflammation
    Publication URI
    http://hdl.handle.net/10072/404270
    Collection
    • Journal articles

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