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dc.contributor.authorBairagi, Anjana
dc.contributor.authorGriffin, Bronwyn
dc.contributor.authorBanani, Tara
dc.contributor.authorMcPhail, Steven M
dc.contributor.authorKimble, Roy
dc.contributor.authorTyack, Zephanie
dc.date.accessioned2021-05-11T05:23:04Z
dc.date.available2021-05-11T05:23:04Z
dc.date.issued2021
dc.identifier.issn0305-4179
dc.identifier.doi10.1016/j.burns.2021.04.005
dc.identifier.urihttp://hdl.handle.net/10072/404303
dc.description.abstractBACKGROUND: This systematic review evaluated the efficacy of autologous skin cell suspensions (ASCS) on the re-epithelialization of partial thickness burn injuries and skin graft donor site wounds. METHODS: Four databases (EMBASE, Google Scholar, MEDLINE, Web of Science), grey literature and select journal hand-searching identified studies from 1975 - 2020. Randomized trials evaluating partial thickness burn management with non-cultured ASCS compared to any other intervention were included. Time to re-epithelialization (TTRE) was the primary outcome. Three independent researchers completed screening, data extraction and certainty of evidence assessment using Cochrane Risk of Bias Tool and Grading of Recommendations Assessment, Development and Evaluation. RESULTS: Five trials (n = 347) reported on adults (2 trials) and children (1 trial) with burn wounds, and adults with donor site wounds (2 trials). The effect of ASCS compared to control on TTRE in adult burn wounds was not estimable. TTRE was shorter in pediatric burn wounds (SMD -1.75 [95% CI: -3.45 to -0.05]) and adult donor site wounds (SMD-5.71 [95% CI: -10.61 to-0.81]) treated with ASCS. The certainty of evidence was very low. CONCLUSION: Compared to standard care, ACSC may reduce pediatric partial thickness burn wound and adult split-thickness skin graft donor site TTRE. REGISTRATION: PROSPERO CRD42019133171.
dc.description.peerreviewedYes
dc.languageeng
dc.publisherElsevier BV
dc.relation.ispartofjournalBurns
dc.subject.fieldofresearchClinical sciences
dc.subject.fieldofresearchcode3202
dc.subject.keywordsAutograft
dc.subject.keywordsBurn
dc.subject.keywordsChild
dc.subject.keywordsDermal
dc.subject.keywordsDonor site wound
dc.titleA systematic review and meta-analysis of randomized trials evaluating the efficacy of autologous skin cell suspensions for re-epithelialization of acute partial thickness burn injuries and split-thickness skin graft donor sites
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationBairagi, A; Griffin, B; Banani, T; McPhail, SM; Kimble, R; Tyack, Z, A systematic review and meta-analysis of randomized trials evaluating the efficacy of autologous skin cell suspensions for re-epithelialization of acute partial thickness burn injuries and split-thickness skin graft donor sites., Burns, 2021
dcterms.dateAccepted2021-04-06
dcterms.licensehttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.date.updated2021-05-11T03:26:14Z
dc.description.versionVersion of Record (VoR)
gro.description.notepublicThis publication has been entered in Griffith Research Online as an advanced online version.
gro.rights.copyright© 2021 Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http:// creativecommons.org/licenses/by-nc-nd/4.0/), which permits unrestricted, non-commercial use, distribution and reproduction in any medium, providing that the work is properly cited.
gro.hasfulltextFull Text
gro.griffith.authorGriffin, Bronwyn R.


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