Show simple item record

dc.contributor.authorFealy, Nigel
dc.contributor.authorAitken, Leanne
dc.contributor.authordu Toit, Eugene
dc.contributor.authorBaldwin, Ian
dc.contributor.authorLo, Serigne
dc.date.accessioned2021-05-13T00:29:26Z
dc.date.available2021-05-13T00:29:26Z
dc.date.issued2017
dc.identifier.issn1036-7314
dc.identifier.doi10.1016/j.aucc.2017.02.003
dc.identifier.urihttp://hdl.handle.net/10072/404337
dc.description.abstractThere is minimal evidence to inform blood flow rate (BFR) during CRRT. We aimed to assess the effect of BFR on circuit life during CRRT. A prospective RCT was conducted over one year in our tertiary ICU. Adult patients with acute kidney injury were randomised to either 150 or 250 mls/min. Circuit and patient data were collected until each circuit clotted or ceased electively. Duration data for clotted circuits are presented as median (Inter-quartile range) and compared using the log-rank test; p was set at <0.05. Circuit clotting data were analysed for repeated events using a hazards ratio (HR). One [AL1] hundred patients were randomised with 96 completing the study (150 mls/min-49; 250 mls/min-47) with 462 circuits; 245:150 mls/min and 217:250 mls/min. Median circuit life for 1st circuit (clotted) was similar for both groups (150 mls/min: 9.1 [5.5, 26] hrs vs. 10 [4.2, 17] hrs; p=0.37). Second and third circuits were also similar. 150 mls/min: 14 [8.5, 21] hrs vs. 13.8 [8.5, 16.7] hrs; p=0.44. 150 mls/min:17 [10.5, 28.5] hrs vs.16 [12,21.5] hrs; p=0.52 respectively. CRRT using 250 mls/min was not more likely to cause clotting compared to 150 mls/min (HR, 1.06 [0.63, 1.78]; p=0.36, variance of the random effect, 1.096 [0.23]). There were no differences in likelihood of clotting for: BMI, weight, vascular access type, length or site, mode of CRRT, INR or platelet count. CRRT with no use of anticoagulation was more likely to cause clotting compared to use of heparin or heparin/protamine (HR 1.61, [1.17, 2.21], p=0.002). Longer APTT was associated with a lower likelihood of circuit clotting (HR 0.98,[0.97, 0.99], p=0.002). Clotting was more probable in males (HR 1.64 [0.87, 3.08] p=0.02). Blood flow rate did not affect clotting during CRRT. Males and use of anticoagulation and APTT were more likely to affect circuit survival.
dc.languageEnglish
dc.publisherElsevier
dc.relation.ispartofconferencename41st ANZICS/ACCCN Annual Scientific Meeting on Intensive Care
dc.relation.ispartofconferencetitleAustralian Critical Care
dc.relation.ispartofdatefrom2016-10-20
dc.relation.ispartofdateto2016-10-22
dc.relation.ispartoflocationPerth, Australia
dc.relation.ispartofpagefrom109
dc.relation.ispartofpageto109
dc.relation.ispartofissue2
dc.relation.ispartofvolume30
dc.subject.fieldofresearchClinical sciences
dc.subject.fieldofresearchNursing
dc.subject.fieldofresearchcode3202
dc.subject.fieldofresearchcode4205
dc.subject.keywordsScience & Technology
dc.subject.keywordsLife Sciences & Biomedicine
dc.subject.keywordsCritical Care Medicine
dc.subject.keywordsGeneral & Internal Medicine
dc.titleBlood flow rate and circuit life in continuous renal replacement therapy (CRRT): a randomised controlled trial (RCT)
dc.typeConference output
dc.type.descriptionE3 - Conferences (Extract Paper)
dcterms.bibliographicCitationFealy, N; Aitken, L; du Toit, E; Baldwin, I; Lo, S, Blood flow rate and circuit life in continuous renal replacement therapy (CRRT): a randomised controlled trial (RCT), Australian Critical Care, 2017, 30 (2), pp. 109-109
dcterms.licensehttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.date.updated2021-05-13T00:27:15Z
dc.description.versionAccepted Manuscript (AM)
gro.rights.copyright© 2017 Australian College of Critical Care Nurses Ltd. Published by Elsevier Australia. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International Licence (http://creativecommons.org/licenses/by-nc-nd/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, providing that the work is properly cited.
gro.hasfulltextFull Text
gro.griffith.authorDu Toit, Eugene
gro.griffith.authorFealy, Nigel
gro.griffith.authorAitken, Leanne M.


Files in this item

This item appears in the following Collection(s)

  • Conference outputs
    Contains papers delivered by Griffith authors at national and international conferences.

Show simple item record