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dc.contributor.authorGuo, Yan
dc.contributor.authorLi, Yantao
dc.contributor.authorZhou, Sijie
dc.contributor.authorYe, Qingsong
dc.contributor.authorZan, Xingjie
dc.contributor.authorHe, Yan
dc.date.accessioned2021-05-13T22:41:18Z
dc.date.available2021-05-13T22:41:18Z
dc.date.issued2021
dc.identifier.issn2373-9878
dc.identifier.doi10.1021/acsbiomaterials.0c01600
dc.identifier.urihttp://hdl.handle.net/10072/404356
dc.description.abstractOwing to high bioactivity and specificity, protein drugs have achieved great success in both diagnosis and therapy. The idea of delivering active proteins directly to targets is becoming more and more attractive. However, due to their large size and environmental sensitivity, it is not easy for proteins to maintain bioactivity in extracellular fluids and cross cell membrane without being damaged. A series of techniques and carriers have been developed to deliver proteins. Thereinto, metal-organic frameworks (MOFs), which are made of metal ions connected by organic linkers, are one of the most important vehicles for protein delivery. Their porous structures, stability, biocompatibility, reproducibility, and the possibility for further functionalities offer great potential for protein delivery. In this review, recent developments of protein encapsulated by MOF nanoparticles, including mechanism of treatment, structural design, loading capacity, delivery, and release properties of proteins, are summarized, and the relationship between structure and performance is emphasized. Meanwhile, further improvements and implementations are discussed.
dc.description.peerreviewedYes
dc.languageeng
dc.publisherAmerican Chemical Society (ACS)
dc.relation.ispartofjournalACS Biomaterials Science & Engineering
dc.subject.fieldofresearchBiomedical Engineering
dc.subject.fieldofresearchcode0903
dc.subject.keywordsbioactive materials
dc.subject.keywordsmetal−organic frameworks
dc.subject.keywordsporous structure
dc.subject.keywordsprotein delivery
dc.subject.keywordsregenerative medicine
dc.titleMetal-Organic Framework-Based Composites for Protein Delivery and Therapeutics
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationGuo, Y; Li, Y; Zhou, S; Ye, Q; Zan, X; He, Y, Metal-Organic Framework-Based Composites for Protein Delivery and Therapeutics., ACS Biomaterials Science & Engineering, 2021
dc.date.updated2021-05-13T06:53:07Z
gro.description.notepublicThis publication has been entered in Griffith Research Online as an advanced online version.
gro.hasfulltextNo Full Text
gro.griffith.authorLi, Yantao


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