• myGriffith
    • Staff portal
    • Contact Us⌄
      • Future student enquiries 1800 677 728
      • Current student enquiries 1800 154 055
      • International enquiries +61 7 3735 6425
      • General enquiries 07 3735 7111
      • Online enquiries
      • Staff phonebook
    View Item 
    •   Home
    • Griffith Research Online
    • Conference outputs
    • View Item
    • Home
    • Griffith Research Online
    • Conference outputs
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

  • All of Griffith Research Online
    • Communities & Collections
    • Authors
    • By Issue Date
    • Titles
  • This Collection
    • Authors
    • By Issue Date
    • Titles
  • Statistics

  • Most Popular Items
  • Statistics by Country
  • Most Popular Authors
  • Support

  • Contact us
  • FAQs
  • Admin login

  • Login
  • Utility of intraluminal thrombolytic therapy for tunnelled haemodialysis catheter dysfunction

    Author(s)
    Yaxley, J
    Kurtkoti, J
    Stockwell, L
    Griffith University Author(s)
    Kurtkoti, Jagadeesh
    Yaxley, Julian P.
    Year published
    2020
    Metadata
    Show full item record
    Abstract
    Aim: To evaluate local practices and the utility of common interventions for tunnelled haemodialysis catheter dysfunction. Background: Catheter dysfunction is a common problem, usually as a result of intraluminal thrombosis. Although scientific evidence is lacking, protocols recommend various conservative measures prior to catheter replacement, such as chest radiography to confirm line position, evaluating fluid status to avoid hypovolaemia, and thrombolytic therapy. Methods: We performed a retrospective chart review of all patients receiving intra‐catheter thrombolysis for catheter dysfunction, over 12 months from August ...
    View more >
    Aim: To evaluate local practices and the utility of common interventions for tunnelled haemodialysis catheter dysfunction. Background: Catheter dysfunction is a common problem, usually as a result of intraluminal thrombosis. Although scientific evidence is lacking, protocols recommend various conservative measures prior to catheter replacement, such as chest radiography to confirm line position, evaluating fluid status to avoid hypovolaemia, and thrombolytic therapy. Methods: We performed a retrospective chart review of all patients receiving intra‐catheter thrombolysis for catheter dysfunction, over 12 months from August 2018 in our metropolitan hospital network. After presenting initial findings to our renal department and instituting a protocol, identical data were prospectively audited for a further 6 months. Results: Thrombolytic therapy was prescribed on 66 occasions over 12 months. Adherence to general guideline recommendations was low. Prior to thrombolysis, chest x‐ray and fluid status was reviewed in only 39% and 18% of patients respectively. Objective criteria defining actual catheter dysfunction was documented in only 44% of patients. Overall, thrombolysis successfully reversed catheter dysfunction in 56% of cases. Chest radiograph acquisition, volume status optimization, and documented presence of actual dysfunction were each associated with greater thrombolysis efficacy. Median catheter survival following thrombolysis was 40 days, and catheter patency at 3 months was 31%. Following our staff education session thrombolytic prescriptions declined by more than 50%. This was accompanied by wider use of protocoled measures and better thrombolysis efficacy. Overall success increased to 75% with a median catheter survival of 75 days. Conclusion: Thrombolytic therapy successfully remediates haemodialysis catheter dysfunction in the majority of cases. Within the limits of a chart review design our findings indicate that observation of routine non‐pharmacological measures and confirmation of catheter dysfunction by objective numerical criteria prior to its use are associated with improved efficacy.
    View less >
    Conference Title
    Nephrology
    Volume
    25
    Issue
    S3
    Publisher URI
    https://onlinelibrary.wiley.com/doi/10.1111/nep.13799
    Subject
    Clinical sciences
    Science & Technology
    Life Sciences & Biomedicine
    Urology & Nephrology
    Publication URI
    http://hdl.handle.net/10072/404390
    Collection
    • Conference outputs

    Footer

    Disclaimer

    • Privacy policy
    • Copyright matters
    • CRICOS Provider - 00233E

    Tagline

    • Gold Coast
    • Logan
    • Brisbane - Queensland, Australia
    First Peoples of Australia
    • Aboriginal
    • Torres Strait Islander