• myGriffith
    • Staff portal
    • Contact Us⌄
      • Future student enquiries 1800 677 728
      • Current student enquiries 1800 154 055
      • International enquiries +61 7 3735 6425
      • General enquiries 07 3735 7111
      • Online enquiries
      • Staff phonebook
    View Item 
    •   Home
    • Griffith Research Online
    • Conference outputs
    • View Item
    • Home
    • Griffith Research Online
    • Conference outputs
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

  • All of Griffith Research Online
    • Communities & Collections
    • Authors
    • By Issue Date
    • Titles
  • This Collection
    • Authors
    • By Issue Date
    • Titles
  • Statistics

  • Most Popular Items
  • Statistics by Country
  • Most Popular Authors
  • Support

  • Contact us
  • FAQs
  • Admin login

  • Login
  • Development and validation of a bronchoscopically defined bronchitis tool in children

    Author(s)
    Eg, K
    Thomas, R
    Masters, I
    Mcelrea, M
    Chang, A
    Griffith University Author(s)
    McElrea, Margaret
    Year published
    2018
    Metadata
    Show full item record
    Abstract
    Introduction/Aim No validated tool exists for scoring bronchitis (i.e. airway inflammation) during flexible bronchoscopy (FB) despite potential clinical and research usefulness. Thus, we aimed to develop a bronchoscopically defined bronchitis scoring system in children (Bscore). Methods We used methods from our retrospective study; FB recordings were assessed for 6 components: amount of secretions (scores 1‐6), colour of secretions (BronkoTest, 0‐8), mucosal oedema (0‐3), ridging (0‐3), erythema (0‐3) and pallor (0‐3) based on pre‐determined criteria. BScore was derived using several models developed from various combinations ...
    View more >
    Introduction/Aim No validated tool exists for scoring bronchitis (i.e. airway inflammation) during flexible bronchoscopy (FB) despite potential clinical and research usefulness. Thus, we aimed to develop a bronchoscopically defined bronchitis scoring system in children (Bscore). Methods We used methods from our retrospective study; FB recordings were assessed for 6 components: amount of secretions (scores 1‐6), colour of secretions (BronkoTest, 0‐8), mucosal oedema (0‐3), ridging (0‐3), erythema (0‐3) and pallor (0‐3) based on pre‐determined criteria. BScore was derived using several models developed from various combinations of the each of the 6 components that best related to airway neutrophilia (in BAL). We also determined the correlations (Spearman) between each component with BAL neutrophil%. Clinical history was obtained from parent(s) who consented for study inclusion before the FB undertaken. A clinician blinded to the child's history scored the FB. The various models of BScore were plotted against neutrophil% using a receiver operating characteristic (ROC) curve. Here we report our preliminary findings; we plan to enrol >100 children. Results Chronic/recurrent cough was the commonest indication for FB in the 30 children enrolled (median age=3‐years). Secretion amount and colour had the strongest correlation with BAL neutrophil%, (r=0.409, p=0.025 and r=0.401, p=0.028 respectively). With inflammation defined as BAL neutrophilia >15%, the highest aROC (0.68, 95%CI 0.45‐0.91) was obtained by tripling the secretion scores (amount and colour) and excluding pallor. aROC for the model derived from our retrospective study was 0.63 (95%CI 0.50‐0.76). The highest aROC (0.86, 95%CI 0.71‐1.00) was with neutrophils of >10% using the BScore obtained by each of the 6 components. Conclusion A validated bronchoscopic defined bronchitis scoring system can be obtained from visualization of airway secretions (amount and colour) and mucosa appearances (erythema, ridging and oedema). Further data is however required.
    View less >
    Conference Title
    Respirology
    Volume
    23
    Issue
    S1
    Publisher URI
    https://onlinelibrary.wiley.com/doi/10.1111/resp.13268
    Subject
    Biomedical and clinical sciences
    Science & Technology
    Life Sciences & Biomedicine
    Respiratory System
    Publication URI
    http://hdl.handle.net/10072/404411
    Collection
    • Conference outputs

    Footer

    Disclaimer

    • Privacy policy
    • Copyright matters
    • CRICOS Provider - 00233E

    Tagline

    • Gold Coast
    • Logan
    • Brisbane - Queensland, Australia
    First Peoples of Australia
    • Aboriginal
    • Torres Strait Islander