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dc.contributor.authorThomas, R
dc.contributor.authorEg, K
dc.contributor.authorMasters, I
dc.contributor.authorMcelrea, M
dc.contributor.authorChang, A
dc.date.accessioned2021-05-14T05:04:38Z
dc.date.available2021-05-14T05:04:38Z
dc.date.issued2018
dc.identifier.issn1323-7799
dc.identifier.urihttp://hdl.handle.net/10072/404412
dc.description.abstractIntroduction/Aim Despite bronchitis being the most common finding at flexible bronchoscopy (FB) in many paediatric centres such as ours, no validated objective system exists. From previously recorded FB, we: (1) determined the correlation among the different macroscopic findings with airway neutrophilia (2) examined the inter‐rater repeatability of these findings and, (3) developed an experimental model of an objective FB‐derived bronchitis score (BScoreexp). Methods We reviewed 100 consecutive previous recordings (2016) from our database. We excluded FBs if: BAL data was unavailable, incomplete FB recording or FBs were on children who were immune‐compromised or had endotracheal tube, tracheostomy or foreign body. FB recordings were assessed (by 2 scorers independently,blinded to the clinical history) for 6 components: amount of secretions (scores 1‐6 from previous validated score), colour of secretions (0‐8 using BronkoTest), mucosal oedema (0‐3), ridging (0‐3), erythema (0‐3) and pallor (0‐3), based on pre‐determined criteria on a pictorial chart. The various models of BScoreexp were plotted against neutrophil% using a receiver operating characteristic (ROC) curve. Here we report our preliminary findings; on the first 65 children with valid FBs. Results Only secretion amount (rs=0.272, p=0.03) and colour (rs=0.342, p=0.005) significantly correlated with BAL %neutrophil but other macroscopic findings correlated with each other. For the 26 FBs examined for repeatability, kappa values for secretions (K=0.96, 95%CI 0.91‐1.0) and colour (K=0.84, 95%CI 0.73‐0.95) were excellent. Other K ranged from 0.38 to 0.67. Using BAL neutrophilia of 15% to define inflammation, the highest aROC (0.63, 95%CI 0.50‐0.76) was obtained by the giving three times weightage to secretion amount and colour and adding it to the other 4 components except pallor. Conclusion A repeatable FB‐defined bronchitis scoring system can be derived. However, a prospective study needs to be performed with larger numbers to further evaluate the different models to obtain aROC of >0.7.
dc.languageEnglish
dc.publisherWiley
dc.publisher.urihttps://onlinelibrary.wiley.com/doi/10.1111/resp.13267
dc.relation.ispartofconferencenameThe Australia & New Zealand Society of Respiratory Science and The Thoracic Society of Australia and New Zealand (ANZSRS/TSANZ) Annual Scientific Meeting
dc.relation.ispartofconferencetitleRespirology
dc.relation.ispartofdatefrom2018-03-23
dc.relation.ispartofdateto2018-03-27
dc.relation.ispartoflocationAdelaide, Australia
dc.relation.ispartofpagefrom28
dc.relation.ispartofpageto28
dc.relation.ispartofissueS1
dc.relation.ispartofvolume23
dc.subject.fieldofresearchBiomedical and clinical sciences
dc.subject.fieldofresearchcode32
dc.subject.keywordsScience & Technology
dc.subject.keywordsLife Sciences & Biomedicine
dc.subject.keywordsRespiratory System
dc.titleCan a bronchoscopically defined bronchitis tool in children be validly developed?
dc.typeConference output
dc.type.descriptionE3 - Conferences (Extract Paper)
dcterms.bibliographicCitationThomas, R; Eg, K; Masters, I; Mcelrea, M; Chang, A, Can a bronchoscopically defined bronchitis tool in children be validly developed?, Respirology, 2018, 23, pp. 28-28
dc.date.updated2021-05-14T05:02:39Z
gro.hasfulltextNo Full Text
gro.griffith.authorMcElrea, Margaret


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