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dc.contributor.authorBong, CY
dc.contributor.authorMark Smithers, B
dc.contributor.authorChua, TC
dc.date.accessioned2021-05-17T04:32:47Z
dc.date.available2021-05-17T04:32:47Z
dc.date.issued2021
dc.identifier.issn2072-1439
dc.identifier.doi10.21037/jtd.2020.03.120
dc.identifier.urihttp://hdl.handle.net/10072/404434
dc.description.abstractMetastatic melanoma is a fatal malignancy with a high mortality and morbidity. Since the early 1970s, available medical therapies were limited in improving survival. Surgery represented the best chance for a cure. However, surgery could only be offered to selected patients. The current landscape of treatment has radically evolved since the introduction of targeted and immunotherapies including BRAF and MEK inhibitors, and checkpoint blockers, like PD-1 and CTLA-4 antibodies. These new therapies have seen survival rates matching, and in some cases surpassing, that of surgery. Anti-PD1 and CTLA-4 combination treatments are associated with severe side effects and BRAF and MEK inhibitor combinations may trigger initial tumour responses but prolonged use have resulted in the development of resistant tumour clones and disease relapse. This review examines the role of pulmonary metastasectomy for lung metastasis from malignant melanoma in the current landscape of effective targeted therapy and immunotherapy.
dc.description.peerreviewedYes
dc.publisherAME Publishing Company
dc.relation.ispartofpagefrom2618
dc.relation.ispartofpageto2627
dc.relation.ispartofissue4
dc.relation.ispartofjournalJournal of Thoracic Disease
dc.relation.ispartofvolume13
dc.subject.fieldofresearchClinical sciences
dc.subject.fieldofresearchcode3202
dc.titlePulmonary metastasectomy in the era of targeted therapy and immunotherapy
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationBong, CY; Mark Smithers, B; Chua, TC, Pulmonary metastasectomy in the era of targeted therapy and immunotherapy, Journal of Thoracic Disease, 2021, 13 (4), pp. 2618-2627
dcterms.licensehttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.date.updated2021-05-17T00:11:52Z
dc.description.versionVersion of Record (VoR)
gro.rights.copyright© The Author(s) 2021. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International (CC BY-NC-ND 4.0) License, which permits unrestricted, non-commercial use, distribution and reproduction in any medium, providing that the work is properly cited.
gro.hasfulltextFull Text
gro.griffith.authorChua, Terence


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