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dc.contributor.authorSadeghi, Masoud
dc.contributor.authorGolshah, Amin
dc.contributor.authorGodiny, Mostafa
dc.contributor.authorSharifi, Roohollah
dc.contributor.authorKhavid, Atefeh
dc.contributor.authorNikkerdar, Nafiseh
dc.contributor.authorTadakamadla, Santosh Kumar
dc.date.accessioned2021-05-17T04:41:09Z
dc.date.available2021-05-17T04:41:09Z
dc.date.issued2021
dc.identifier.issn2227-9067
dc.identifier.doi10.3390/children8040302
dc.identifier.urihttp://hdl.handle.net/10072/404436
dc.description.abstractVitamin D participates in the calcification of enamel and dentin and the appropriate immune responses to oral microbial infections. We aimed to assess the association between the most common vitamin D receptor (VDR) polymorphisms (ApaI,FokI, TaqI, BsmI, and BglI) and the risk of dental caries in children. METHODS: PubMed/MEDLINE, Cochrane Library, Web of Science, and Scopus databases were comprehensively searched until 19 January 2021. Meta-analysis with odds ratios as the effect estimate along with 95% confidence intervals and subgroup analysis were conducted using Review Manager 5.3 software. Publication bias and sensitivity analyses were conducted by Comprehensive Meta-Analysis, version 2.0 software. RESULTS: Seventy-eight studies were retrieved from the databases, with nine studies included in the final analysis. Based on five genetic models, there was no association between ApaI (rs7975232), TaqI (rs731236), BsmI (rs1544410), FokI (rs2228570), and BglI (rs739837) polymorphisms and susceptibility to dental caries, except for the FokI (rs10735810) polymorphism. CONCLUSION: Among the VDR polymorphisms considered, an association was found between the FokI (rs10735810) polymorphism and the risk of dental caries, with a protective role of the f allele and ff genotype.
dc.description.peerreviewedYes
dc.languageEnglish
dc.publisherMDPI
dc.relation.ispartofpagefrom302
dc.relation.ispartofissue4
dc.relation.ispartofjournalChildren
dc.relation.ispartofvolume8
dc.subject.fieldofresearchPaediatrics
dc.subject.fieldofresearchReproductive medicine
dc.subject.fieldofresearchcode3213
dc.subject.fieldofresearchcode3215
dc.subject.keywordsScience & Technology
dc.subject.keywordsLife Sciences & Biomedicine
dc.subject.keywordsPediatrics
dc.subject.keywordsdental caries
dc.subject.keywordstooth decay
dc.titleThe Most Common Vitamin D Receptor Polymorphisms (ApaI,FokI, TaqI, BsmI, and BglI) in Children with Dental Caries: A Systematic Review and Meta-Analysis
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationSadeghi, M; Golshah, A; Godiny, M; Sharifi, R; Khavid, A; Nikkerdar, N; Tadakamadla, SK, The Most Common Vitamin D Receptor Polymorphisms (ApaI,FokI, TaqI, BsmI, and BglI) in Children with Dental Caries: A Systematic Review and Meta-Analysis, Children , 2021, 8 (4), pp. 302
dcterms.dateAccepted2021-04-12
dcterms.licensehttps://creativecommons.org/licenses/by/4.0/
dc.date.updated2021-05-17T00:30:21Z
dc.description.versionVersion of Record (VoR)
gro.rights.copyright© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
gro.hasfulltextFull Text
gro.griffith.authorTadakamadla, Santosh Kumar


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