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dc.contributor.authorGopinath, Divya
dc.contributor.authorMenon, Rohit Kunnath
dc.contributor.authorWie, Chong Chun
dc.contributor.authorBanerjee, Moinak
dc.contributor.authorPanda, Swagatika
dc.contributor.authorMandal, Deviprasad
dc.contributor.authorBehera, Paresh Kumar
dc.contributor.authorRoychoudhury, Susanta
dc.contributor.authorKheur, Supriya
dc.contributor.authorBotelho, Michael George
dc.contributor.authorJohnson, Newell W
dc.date.accessioned2021-05-18T00:02:31Z
dc.date.available2021-05-18T00:02:31Z
dc.date.issued2021
dc.identifier.issn2000-2297
dc.identifier.doi10.1080/20002297.2020.1857998
dc.identifier.urihttp://hdl.handle.net/10072/404443
dc.description.abstractObjective: While some oral carcinomas appear to arise de novo, others develop within long-standing conditions of the oral cavity that have malignant potential, now known as oral potentially malignant disorders (OPMDs). The oral bacteriome associated with OPMD has been studied to a lesser extent than that associated with oral cancer. To characterize the association in detail we compared the bacteriome in whole mouth fluid (WMF) in patients with oral leukoplakia, oral cancer and healthy controls. Methods: WMF bacteriome from 20 leukoplakia patients, 31 patients with oral cancer and 23 healthy controls were profiled using the Illumina MiSeq platform. Sequencing reads were processed using DADA2, and taxonomical classification was performed using the phylogenetic placement method. Sparse Partial Least Squares Regression Discriminant Analysis model was used to identify bacterial taxa that best discriminate the studied groups. Results: We found considerable overlap between the WMF bacteriome of leukoplakia and oral cancer while a clearer separation between healthy controls and the former two disorders was observed. Specifically, the separation was attributed to 14 taxa belonging to the genera Megaspheara, unclassified enterobacteria, Prevotella, Porphyromonas, Rothia and Salmonella, Streptococcus, and Fusobacterium. The most discriminative bacterial genera between leukoplakia and oral cancer were Megasphaera, unclassified Enterobacteriae, Salmonella and Prevotella. Conclusion: Oral bacteria may play a role in the early stages of oral carcinogenesis as a dysbiotic bacteriome is associated with oral leukoplakia and this resembles that of oral cancer more than healthy controls. Our findings may have implications for developing oral cancer prevention strategies targeting early microbial drivers of oral carcinogenesis.
dc.description.peerreviewedYes
dc.languageEnglish
dc.publisherTaylor & Francis Group
dc.relation.ispartofpagefrom1857998
dc.relation.ispartofissue1
dc.relation.ispartofjournalJournal of Oral Microbiology
dc.relation.ispartofvolume13
dc.subject.fieldofresearchMedical microbiology
dc.subject.fieldofresearchcode3207
dc.subject.keywordsScience & Technology
dc.subject.keywordsLife Sciences & Biomedicine
dc.subject.keywordsMicrobiology
dc.subject.keywordsSaliva
dc.subject.keywordsbacteriome
dc.titleSalivary bacterial shifts in oral leukoplakia resemble the dysbiotic oral cancer bacteriome
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationGopinath, D; Menon, RK; Wie, CC; Banerjee, M; Panda, S; Mandal, D; Behera, PK; Roychoudhury, S; Kheur, S; Botelho, MG; Johnson, NW, Salivary bacterial shifts in oral leukoplakia resemble the dysbiotic oral cancer bacteriome, Journal of Oral Microbiology, 2021, 13 (1), pp. 1857998
dcterms.licensehttps://creativecommons.org/licenses/by/4.0/
dc.date.updated2021-05-17T01:33:38Z
dc.description.versionVersion of Record (VoR)
gro.rights.copyright© 2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
gro.hasfulltextFull Text
gro.griffith.authorJohnson, Newell W.


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