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dc.contributor.authorSimerska, Pavlaen_US
dc.contributor.authorM. Abdel-Aal, Abu-Bakeren_US
dc.contributor.authorFujita, Yoshioen_US
dc.contributor.authorM. Moyle, Peteren_US
dc.contributor.authorP. McGeary, Rossen_US
dc.contributor.authorR. Batzloff, Michaelen_US
dc.contributor.authorOlive, Colleenen_US
dc.contributor.authorF. Good, Michaelen_US
dc.contributor.authorToth, Istvanen_US
dc.date.accessioned2017-04-24T09:58:27Z
dc.date.available2017-04-24T09:58:27Z
dc.date.issued2008en_US
dc.date.modified2014-01-08T04:56:04Z
dc.identifier.issn00222623en_US
dc.identifier.doi10.1021/jm701410pen_US
dc.identifier.urihttp://hdl.handle.net/10072/40446
dc.description.abstractGroup A streptococcus (GAS) is associated with many human diseases, ranging in severity from benign to life-threatening. A promising strategy for developing vaccines against GAS involves the use of carbohydrates as carriers for peptide antigens. This study describes the optimized synthesis of d-glucose and d-galactose derived carriers, bearing an adipate linker and four tert-butoxycarbonyl protected aminopropyl groups. Prophylactic GAS vaccine candidates were synthesized by conjugating multiple copies of a single GAS M protein derived peptide antigen (either J8 or J14) onto the carbohydrate carriers. These antigens contain peptide sequences, which are highly conserved and offer the potential to prevent infections caused by up to 70% of GAS strains. Lipophilic amino acids were also conjugated to the d-glucose anomeric carbon to produce a self-adjuvanting liposaccharide vaccine. High serum IgG antibody titers against each of the incorporated peptide epitopes were detected following subcutaneous immunization of B10.BR (H-2k) mice with the liposaccharide vaccine candidates.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_US
dc.languageEnglishen_US
dc.language.isoen_US
dc.publisherAmerican Chemical Societyen_US
dc.publisher.placeUnited Statesen_US
dc.relation.ispartofstudentpublicationNen_US
dc.relation.ispartofpagefrom1447en_US
dc.relation.ispartofpageto1452en_US
dc.relation.ispartofissue5en_US
dc.relation.ispartofjournalJournal of Medicinal Chemistryen_US
dc.relation.ispartofvolume51en_US
dc.rights.retentionYen_US
dc.subject.fieldofresearchInfectious Agentsen_US
dc.subject.fieldofresearchcode060502en_US
dc.titleDevelopment of a Liposaccharide-Based Delivery System and Its Application to the Design of Group A Streptococcal Vaccinesen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.rights.copyrightSelf-archiving of the author-manuscript version is not yet supported by this journal. Please refer to the journal link for access to the definitive, published version or contact the author[s] for more information.en_US
gro.date.issued2008
gro.hasfulltextNo Full Text


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