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  • Clinical use of Jak 1 inhibitors for rheumatoid arthritis

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    Nash492277-Published.pdf (559.4Kb)
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    Author(s)
    Nash, Peter
    Griffith University Author(s)
    Nash, Peter
    Year published
    2021
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    Abstract
    The uptake of Jak inhibitors in the RA space has been among the most rapid in rheumatology, based on the results of comprehensive clinical trial programmes of five agents. Newer generations of Jak inhibitors, like upadacitinib and filgotinib, target Jak 1 selectively with the aim of maximizing efficacy and to improve safety. This article will review the clinical significance of evidence on: (i) Jak 1 selectivity; (ii) efficacy from the SELECT and FINCH clinical trial programmes including patient intolerant or inadequately responding to MTX (MTX-IR) and other csDMARDs patients who are bDMARD-IR) and those using monotherapy ...
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    The uptake of Jak inhibitors in the RA space has been among the most rapid in rheumatology, based on the results of comprehensive clinical trial programmes of five agents. Newer generations of Jak inhibitors, like upadacitinib and filgotinib, target Jak 1 selectively with the aim of maximizing efficacy and to improve safety. This article will review the clinical significance of evidence on: (i) Jak 1 selectivity; (ii) efficacy from the SELECT and FINCH clinical trial programmes including patient intolerant or inadequately responding to MTX (MTX-IR) and other csDMARDs patients who are bDMARD-IR) and those using monotherapy when MTX is not tolerated or contraindicated and those treated when methotrexate naive; and (iii) safety from the clinical trial programmes of these two agents will be discussed.
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    Journal Title
    Rheumatology
    Volume
    60
    Issue
    Supplement_2
    DOI
    https://doi.org/10.1093/rheumatology/keab265
    Copyright Statement
    © The Author(s) 2021. Published by Oxford University Press on behalf of the British Society for Rheumatology. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
    Subject
    Clinical sciences
    Immunology
    Health services and systems
    Public health
    Jak 1 selectivity
    efficacy
    filgotinib
    safety
    upadacitinib
    Publication URI
    http://hdl.handle.net/10072/404501
    Collection
    • Journal articles

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