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  • Pre-clinical evaluation of a whole-parasite vaccine to control human babesiosis

    Author(s)
    Al-Nazal, Hanan A
    Cooper, Emily
    Ho, Mei Fong
    Eskandari, Sharareh
    Majam, Victoria
    Giddam, Ashwini Kumar
    Hussein, Waleed M
    Islam, Md Tanjir
    Skwarczynski, Mariusz
    Toth, Istvan
    Kumar, Sanjai
    Zaid, Ali
    Batzloff, Michael
    Stanisic, Danielle I
    Good, Michael F
    Griffith University Author(s)
    Good, Michael F.
    Stanisic, Danielle
    Eskandari, Sherry
    Al-Nazal, Hanan A.
    Cooper, Emily K.
    Ho, Mei Fong
    Giddam, Ashwin Kumar K.
    Zaid, Ali
    Batzloff, Michael R.
    Year published
    2021
    Metadata
    Show full item record
    Abstract
    Babesia spp. are tick-transmitted intra-erythrocytic protozoan parasites that infect humans and animals, causing a flu-like illness and hemolytic anemia. There is currently no human vaccine available. People most at risk of severe disease are the elderly, immunosuppressed, and asplenic individuals. B. microti and B. divergens are the predominant species affecting humans. Here, we present a whole-parasite Babesia vaccine. To establish proof-of-principle, we employed chemically attenuated B. microti parasitized red blood cells from infected mice. To aid clinical translation, we produced liposomes containing killed parasite ...
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    Babesia spp. are tick-transmitted intra-erythrocytic protozoan parasites that infect humans and animals, causing a flu-like illness and hemolytic anemia. There is currently no human vaccine available. People most at risk of severe disease are the elderly, immunosuppressed, and asplenic individuals. B. microti and B. divergens are the predominant species affecting humans. Here, we present a whole-parasite Babesia vaccine. To establish proof-of-principle, we employed chemically attenuated B. microti parasitized red blood cells from infected mice. To aid clinical translation, we produced liposomes containing killed parasite material. Vaccination significantly reduces peak parasitemia following challenge. B cells and anti-parasite antibodies do not significantly contribute to vaccine efficacy. Protection is abrogated by the removal of CD4+ T cells or macrophages prior to challenge. Importantly, splenectomized mice are protected by vaccination. To further facilitate translation, we prepared a culture-based liposomal vaccine and demonstrate that this performs as a universal vaccine inducing immunity against different human Babesia species.
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    Journal Title
    Cell Host & Microbe
    DOI
    https://doi.org/10.1016/j.chom.2021.04.008
    Note
    This publication has been entered in Griffith Research Online as an advanced online version.
    Subject
    Microbiology
    Medical microbiology
    B. divergens
    B. microti
    Babesia
    T cells
    heterologous protection
    Publication URI
    http://hdl.handle.net/10072/404554
    Collection
    • Journal articles

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