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dc.contributor.authorJing, Jingen_US
dc.contributor.authorRen, Weichaoen_US
dc.contributor.authorChen, Xijingen_US
dc.contributor.authorWang, Yueen_US
dc.contributor.authorYu, Qiaolingen_US
dc.contributor.authorWang, Guangjien_US
dc.contributor.authorK. Davey, Andrewen_US
dc.contributor.authorWang, Jipingen_US
dc.contributor.authorJing, Ningen_US
dc.date.accessioned2017-04-24T11:20:20Z
dc.date.available2017-04-24T11:20:20Z
dc.date.issued2008en_US
dc.date.modified2011-10-24T07:26:26Z
dc.identifier.issn13474367en_US
dc.identifier.urihttp://hdl.handle.net/10072/40455
dc.description.abstractTo study the metabolites of glycyrrhetic acid (GA) in rat bile, an analytical method was developed to identify GA and its metabolites by liquid chromatography mass spectrometry (LC-MS). Rat bile was collected after i.v. injection of GA. Three major GA-related peaks were detectable in rat bile by high-performance liquid chromatography (HPLC) analysis at 254 nm. LC-MS spectra showed their protonated molecular ions at m/z 727, 647, and 551. Furthermore, the three metabolites were also confirmed to exist in rat bile on LC-MS total ion chromatogram (TIC). Taken together with the susceptible nature to ߭glucuronidase digestion and alkaline conditions, they were identified to be a novel sulfate-glucuronide diconjugate and the known monoglucuronide and sulfate conjugate, respectively.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_AU
dc.format.extent545263 bytes
dc.format.mimetypeapplication/pdf
dc.languageEnglishen_US
dc.language.isoen_AU
dc.publisherYakubutsu Dotai Gakkaien_US
dc.publisher.placeJapanen_US
dc.publisher.urihttp://www.jstage.jst.go.jp/article/dmpk/23/3/23_175/_articleen_AU
dc.relation.ispartofstudentpublicationNen_AU
dc.relation.ispartofpagefrom175en_US
dc.relation.ispartofpageto180en_US
dc.relation.ispartofissue3en_US
dc.relation.ispartofjournalDrug Metabolism and Pharmacokineticsen_US
dc.relation.ispartofvolume23en_US
dc.rights.retentionYen_AU
dc.subject.fieldofresearchBasic Pharmacologyen_US
dc.subject.fieldofresearchcode111501en_US
dc.titleGlucuronide-sulfate diconjugate as a novel metabolite of glycyrrhetic acid in rat bileen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.rights.copyrightCopyright 2008 The Japanese Society for the Study of Xenobiotics (JSSX). The attached file is reproduced here in accordance with the copyright policy of the publisher. Please refer to the conference's website for access to the definitive, published version.en_AU
gro.date.issued2008
gro.hasfulltextFull Text


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