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  • Microneedle arrays for sampling and sensing skin interstitial fluid

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    Kashaninejad478564-Published.pdf (3.721Mb)
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    Version of Record (VoR)
    Author(s)
    Kashaninejad, N
    Munaz, A
    Moghadas, H
    Yadav, S
    Umer, M
    Nguyen, NT
    Griffith University Author(s)
    Umer, Muhammad
    Kashaninejad, Navid
    Nguyen, Nam-Trung
    Yadav, Sharda
    Year published
    2021
    Metadata
    Show full item record
    Abstract
    Dermal interstitial fluid (ISF) is a novel source of biomarkers that can be considered as an alternative to blood sampling for disease diagnosis and treatment. Nevertheless, in vivo extraction and analysis of ISF are challenging. On the other hand, microneedle (MN) technology can address most of the challenges associated with dermal ISF extraction and is well suited for long-term, continuous ISF monitoring as well as in situ detection. In this review, we first briefly summarise the different dermal ISF collection methods and compare them with MN methods. Next, we elaborate on the design considerations and biocompatibility ...
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    Dermal interstitial fluid (ISF) is a novel source of biomarkers that can be considered as an alternative to blood sampling for disease diagnosis and treatment. Nevertheless, in vivo extraction and analysis of ISF are challenging. On the other hand, microneedle (MN) technology can address most of the challenges associated with dermal ISF extraction and is well suited for long-term, continuous ISF monitoring as well as in situ detection. In this review, we first briefly summarise the different dermal ISF collection methods and compare them with MN methods. Next, we elaborate on the design considerations and biocompatibility of MNs. Subsequently, the fabrication technologies of various MNs used for dermal ISF extraction, including solid MNs, hollow MNs, porous MNs, and hydrogel MNs, are thoroughly explained. In addition, different sensing mechanisms of ISF detection are discussed in detail. Subsequently, we identify the challenges and propose the possible solutions associated with ISF extraction. A detailed investigation is provided for the transport and sampling mechanism of ISF in vivo. Also, the current in vitro skin model integrated with the MN arrays is discussed. Finally, future directions to develop a point-of-care (POC) device to sample ISF are proposed.
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    Journal Title
    Chemosensors
    Volume
    9
    Issue
    4
    DOI
    https://doi.org/10.3390/chemosensors9040083
    Copyright Statement
    © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
    Subject
    Clinical sciences
    Biomedical and clinical sciences
    Biomechanical engineering
    Publication URI
    http://hdl.handle.net/10072/404690
    Collection
    • Journal articles

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