Platinum complexes act as shielding agents against virus infection
Author(s)
Bailly, Benjamin
Gorle, Anil K
Dirr, Larissa
Malde, Alpeshkumar K
Farrell, Nicholas P
Berners-Price, Susan J
von Itzstein, Mark
Griffith University Author(s)
Year published
2021
Metadata
Show full item recordAbstract
We determine that the substitution-inert polynuclear platinum complex (PPC) TriplatinNC is an antiviral agent and protects cells from enterovirus 71 and human metapneumovirus infection. This protection occurs through the formation of adducts with cell-surface glycosaminoglycans. Our detailed mechanistic investigation demonstrates that TriplatinNC blocks viral entry by shielding cells from virus attack, opening new directions for metalloshielding antiviral drug development.We determine that the substitution-inert polynuclear platinum complex (PPC) TriplatinNC is an antiviral agent and protects cells from enterovirus 71 and human metapneumovirus infection. This protection occurs through the formation of adducts with cell-surface glycosaminoglycans. Our detailed mechanistic investigation demonstrates that TriplatinNC blocks viral entry by shielding cells from virus attack, opening new directions for metalloshielding antiviral drug development.
View less >
View less >
Journal Title
Chemical Communications
Volume
57
Issue
38
Subject
Virology
Clinical sciences
Chemical sciences
Science & Technology
Physical Sciences
Chemistry, Multidisciplinary
Chemistry