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dc.contributor.authorMpala, Lindiwe Nomathemba
dc.contributor.authorChikowe, Getmore Rumbudzai
dc.contributor.authorCock, Ian Edwin
dc.date.accessioned2021-06-02T00:17:58Z
dc.date.available2021-06-02T00:17:58Z
dc.date.issued2021
dc.identifier.issn2249-0167
dc.identifier.doi10.5530/pc.2021.1.9
dc.identifier.urihttp://hdl.handle.net/10072/404815
dc.description.abstractIntroduction: The recent development of extensively antibiotic resistant bacteria has necessitated the search for novel antibacterial compounds. An examination of aromatic plants and traditional medicines is an attractive option for drug discovery. Astrotrichia latifolia Benth. is a native Australia shrub that has yet to be tested for antibacterial activity. Methods: The ability of A. latifolia leaf extracts to inhibit the growth of a panel of bacterial pathogens was investigated by disc diffusion assay. Toxicity was examined using the Artemia franciscana nauplii bioassay. Results: A. latifolia leaf methanolic and aqueous extracts were completely ineffective at inhibiting the growth of gram-positive and gram-negative panels of bacteria. The extracts were non-toxic in the Artemia nauplii bioassay following 24 h exposure. Conclusion: A. latifolia leaf extracts were completely ineffective bacterial growth inhibitors. However, these extracts may have other therapeutic properties and testing against protozoa, virus and tumour cells is required.
dc.description.peerreviewedYes
dc.publisherPharmacognosy Network Worldwide
dc.relation.ispartofpagefrom40
dc.relation.ispartofpageto44
dc.relation.ispartofissue1
dc.relation.ispartofjournalPharmacognosy Communications
dc.relation.ispartofvolume11
dc.subject.fieldofresearchPlant Biology
dc.subject.fieldofresearchPharmacology and Pharmaceutical Sciences
dc.subject.fieldofresearchcode0607
dc.subject.fieldofresearchcode1115
dc.titleAstrotrichia latifolia Benth. Leaf Extracts Lack Antibacterial Activity and are Non-toxic in vitro
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationMpala, LN; Chikowe, GR; Cock, IE, Astrotrichia latifolia Benth. Leaf Extracts Lack Antibacterial Activity and are Non-toxic in vitro, Pharmacognosy Communications, 2021, 11 (1), pp. 40-44
dcterms.licensehttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.date.updated2021-06-01T20:56:57Z
dc.description.versionVersion of Record (VoR)
gro.rights.copyright© The Author(s) 2021. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International (CC BY-NC-ND 4.0) License (http://creativecommons.org/licenses/by-nc-nd/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, providing that the work is properly cited.
gro.hasfulltextFull Text
gro.griffith.authorCock, Ian E.
gro.griffith.authorMpala, Lindiwe N.
gro.griffith.authorChikowe, Getmore R.


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