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dc.contributor.authorCock, Ian Edwin
dc.date.accessioned2021-06-02T00:23:42Z
dc.date.available2021-06-02T00:23:42Z
dc.date.issued2021
dc.identifier.issn2249-0159
dc.identifier.doi10.5530/pc.2021.2.19
dc.identifier.urihttp://hdl.handle.net/10072/404818
dc.description.abstractIntroduction: The development of bacterial strains that are resistant to multiple antibiotics has made the discovery of new antibiotics a priority for medical research. Examination of plants for new antimicrobial agents is an attractive prospect and numerous recent studies have screened plants for antibacterial activity. Despite this, Australian native plants have been relatively neglected. Mirbelia oxylobioides F.Muell. is a native Australian shrub of the family Fabaceae. Very few studies have yet examined species for antibacterial properties against human pathogens. Methods: The ability of M. oxyloboides leaf extracts to inhibit the growth of a panel of bacterial pathogens was investigated by disc diffusion assay. Toxicity was examined using the Artemia franciscana nauplii bioassay. Results: M. oxyloboides methanolic and aqueous extracts were ineffective at inhibiting the growth of gram-positive and gram-negative panels of bacteria. The extracts were nontoxic or of low toxicity following 24 h exposure. Conclusion: The M. oxyloboides leaf extracts lacked growth inhibitory bioactivity against a panel of pathogenic bacteria and were nontoxic in the Artemia nauplii assay. However, these extracts may have other therapeutic properties and testing against protozoa, fungi, virus and tumour cells is required.
dc.description.peerreviewedYes
dc.publisherPharmacognosy Network Worldwide
dc.relation.ispartofpagefrom95
dc.relation.ispartofpageto99
dc.relation.ispartofissue2
dc.relation.ispartofjournalPharmacognosy Communications
dc.relation.ispartofvolume11
dc.subject.fieldofresearchPlant Biology
dc.subject.fieldofresearchPharmacology and Pharmaceutical Sciences
dc.subject.fieldofresearchcode0607
dc.subject.fieldofresearchcode1115
dc.titleMirbelia oxylobioides F. Muell. Leaf Extracts Lack Antibacterial Activity and are Non-toxic in vitro
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationCock, IE, Mirbelia oxylobioides F. Muell. Leaf Extracts Lack Antibacterial Activity and are Non-toxic in vitro, Pharmacognosy Communications, 2021, 11 (2), pp. 95-99
dcterms.licensehttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.date.updated2021-06-01T21:01:13Z
dc.description.versionVersion of Record (VoR)
gro.rights.copyright© The Author(s) 2021. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International (CC BY-NC-ND 4.0) License (http://creativecommons.org/licenses/by-nc-nd/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, providing that the work is properly cited.
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gro.griffith.authorCock, Ian E.


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