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dc.contributor.authorHou, Xun-Yaen_US
dc.contributor.authorMcManus, Donalden_US
dc.contributor.authorGray, Darrenen_US
dc.contributor.authorBalen, Julieen_US
dc.contributor.authorLuo, Xin-Songen_US
dc.contributor.authorHe, Yong-Kangen_US
dc.contributor.authorEllis, Magdaen_US
dc.contributor.authorWilliams, Gail M.en_US
dc.contributor.authorLi, Yue-Shengen_US
dc.date.accessioned2017-04-24T11:15:25Z
dc.date.available2017-04-24T11:15:25Z
dc.date.issued2008en_US
dc.date.modified2011-08-30T06:21:55Z
dc.identifier.issn00429686en_US
dc.identifier.doi10.2471/BLT.08.053041en_AU
dc.identifier.urihttp://hdl.handle.net/10072/40482
dc.description.abstractObjective To evaluate the safety and efficacy of combining artemether (AM) and praziquantel (PZQ) in different regimens for treating acute schistosomiasis japonica. Methods We undertook a randomized, double-blind, placebo-controlled trial within four specialized schistosomiasis hospitals in the Dongting Lake region, Hunan province, China, between May 2003 and December 2005. Study participants were randomized into one of four treatment regimes: group A received 60 mg/kg PZQ + 6 mg/kg AM; group B received 60 mg/kg PZQ + AM placebo; group C received 120 mg/kg PZQ + 6 mg/kg AM; and group D received 120 mg/kg PZQ + AM placebo. All participants were followed up over a 45-day period. The primary endpoint of the trial was human infection status (determined by positive stool examination). Secondary endpoints involved clinical observations and blood biochemistry, including monitoring haemoglobin and alanine aminotransferase levels over time. Findings Treatment efficacies of the four different treatment regimens were 98.0%, 96.4%, 97.7% and 95.7% for group A, B, C, and D respectively (P > 0.05). The group B had a greater treatment efficacy (96.4%) than the group D (95.7%) (P > 0.05). Group A treatment was better for clearance of fever (P < 0.05) and resulted in a shorter hospitalization time (P < 0.05). Conclusion This is the first report of a randomized, double-blind, placebo-controlled trial for evaluating combined chemotherapy with AM and two different dosages (60 mg/kg and 120 mg/kg) of PZQ in the treatment of acute schistosomiasis japonica in China. The combination of AM and PZQ chemotherapy did not improve treatment efficacy compared with PZQ alone. PZQ given as a dosage of 60 mg/kg (1 day, 3 נ20 mg/kg doses at 4-5 hour intervals) may be as effective as a dosage of 120 mg/kg (6 days, 20 mg/kg for each day split into 3 doses at 4-5 hour intervals).en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_AU
dc.format.extent853516 bytes
dc.format.mimetypeapplication/pdf
dc.languageEnglishen_US
dc.language.isoen_AU
dc.publisherWorld Health Organizationen_US
dc.publisher.placeSwitzerlanden_US
dc.relation.ispartofstudentpublicationNen_AU
dc.relation.ispartofpagefrom788en_US
dc.relation.ispartofpageto795en_US
dc.relation.ispartofissue10en_US
dc.relation.ispartofjournalBulletin of the World Health Organizationen_US
dc.relation.ispartofvolume86en_US
dc.rights.retentionYen_AU
dc.subject.fieldofresearchEpidemiologyen_US
dc.subject.fieldofresearchcode111706en_US
dc.titleA randomised, double-blind, placebo-controlled trial on the safety and efficacy of combined praziquantel and artemether treatment for acute schistosomiasis japonica in Chinaen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.rights.copyrightCopyright 2008 World Health Organization. The attached file is reproduced here in accordance with the copyright policy of the publisher. Please refer to the journal's website for access to the definitive, published version.en_AU
gro.date.issued2008
gro.hasfulltextFull Text


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