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dc.contributor.authorHou, Xun-Ya
dc.contributor.authorMcManus, Donald
dc.contributor.authorGray, Darren
dc.contributor.authorBalen, Julie
dc.contributor.authorLuo, Xin-Song
dc.contributor.authorHe, Yong-Kang
dc.contributor.authorEllis, Magda
dc.contributor.authorWilliams, Gail M.
dc.contributor.authorLi, Yue-Sheng
dc.date.accessioned2017-05-03T14:01:24Z
dc.date.available2017-05-03T14:01:24Z
dc.date.issued2008
dc.date.modified2011-08-30T06:21:55Z
dc.identifier.issn00429686
dc.identifier.doi10.2471/BLT.08.053041
dc.identifier.urihttp://hdl.handle.net/10072/40482
dc.description.abstractObjective To evaluate the safety and efficacy of combining artemether (AM) and praziquantel (PZQ) in different regimens for treating acute schistosomiasis japonica. Methods We undertook a randomized, double-blind, placebo-controlled trial within four specialized schistosomiasis hospitals in the Dongting Lake region, Hunan province, China, between May 2003 and December 2005. Study participants were randomized into one of four treatment regimes: group A received 60 mg/kg PZQ + 6 mg/kg AM; group B received 60 mg/kg PZQ + AM placebo; group C received 120 mg/kg PZQ + 6 mg/kg AM; and group D received 120 mg/kg PZQ + AM placebo. All participants were followed up over a 45-day period. The primary endpoint of the trial was human infection status (determined by positive stool examination). Secondary endpoints involved clinical observations and blood biochemistry, including monitoring haemoglobin and alanine aminotransferase levels over time. Findings Treatment efficacies of the four different treatment regimens were 98.0%, 96.4%, 97.7% and 95.7% for group A, B, C, and D respectively (P > 0.05). The group B had a greater treatment efficacy (96.4%) than the group D (95.7%) (P > 0.05). Group A treatment was better for clearance of fever (P < 0.05) and resulted in a shorter hospitalization time (P < 0.05). Conclusion This is the first report of a randomized, double-blind, placebo-controlled trial for evaluating combined chemotherapy with AM and two different dosages (60 mg/kg and 120 mg/kg) of PZQ in the treatment of acute schistosomiasis japonica in China. The combination of AM and PZQ chemotherapy did not improve treatment efficacy compared with PZQ alone. PZQ given as a dosage of 60 mg/kg (1 day, 3 נ20 mg/kg doses at 4-5 hour intervals) may be as effective as a dosage of 120 mg/kg (6 days, 20 mg/kg for each day split into 3 doses at 4-5 hour intervals).
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.format.extent853516 bytes
dc.format.mimetypeapplication/pdf
dc.languageEnglish
dc.language.isoeng
dc.publisherWorld Health Organization
dc.publisher.placeSwitzerland
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom788
dc.relation.ispartofpageto795
dc.relation.ispartofissue10
dc.relation.ispartofjournalBulletin of the World Health Organization
dc.relation.ispartofvolume86
dc.rights.retentionY
dc.subject.fieldofresearchEpidemiology
dc.subject.fieldofresearchMedical and Health Sciences
dc.subject.fieldofresearchcode111706
dc.subject.fieldofresearchcode11
dc.titleA randomised, double-blind, placebo-controlled trial on the safety and efficacy of combined praziquantel and artemether treatment for acute schistosomiasis japonica in China
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.rights.copyright© 2008 World Health Organization. The attached file is reproduced here in accordance with the copyright policy of the publisher. Please refer to the journal's website for access to the definitive, published version.
gro.date.issued2008
gro.hasfulltextFull Text
gro.griffith.authorGray, Darren


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