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dc.contributor.authorMpala, Lindiwe
dc.contributor.authorChikowe, Getmore
dc.contributor.authorCock, Ian Edwin
dc.date.accessioned2021-06-02T01:26:26Z
dc.date.available2021-06-02T01:26:26Z
dc.date.issued2019
dc.identifier.issn2249-0159
dc.identifier.doi10.5530/pc.2019.1.6
dc.identifier.urihttp://hdl.handle.net/10072/404836
dc.description.abstractIntroduction: Streptococcus pyogenes is a gram positive pathogenic bacterium which causes a variety of diseases including streptococcal pharyngitis, impetigo and rheumatic heart disease. Many Brachychiton spp. have reported uses to treat pathogenic illness and are rich in flavonoids with reported antibacterial activity. Despite this, B. rupestris leaf extracts have not previously been examined for bacterial growth inhibitory properties. Methods: The ability of B. rupestris leaf extracts to inhibit the growth of S. pyogenes was investigated by disc diffusion and growth time course assays. The growth inhibitory activity was further quantified by MIC determination. Toxicity was determined using the Artemia franciscana nauplii bioassay. Results: The methanolic and aqueous B. rupestris leaf extracts were potent inhibitors of S. pyogenes growth, with MIC values as low as 445μg/mL. The antibacterial activity of the methanolic and aqueous B. rupestris leaf extracts were further investigated by growth time course assays that showed significant growth inhibition within 1h of exposure. All extracts were determined to be nontoxic in the Artemia franciscana nauplii bioassay, indicating their safety for use in preventing S. pyogenes associated diseases caused by these pathogens. Conclusion: The lack of toxicity of the B. rupestris leaf extracts and their growth inhibitory bioactivity against S. pyogenes indicate their potential in the development of new therapies for rheumatic fever, pharyngitis, impetigo and other illnesses caused by this bacterium.
dc.description.peerreviewedYes
dc.publisherPharmacognosy Network Worldwide
dc.relation.ispartofpagefrom27
dc.relation.ispartofpageto33
dc.relation.ispartofissue1
dc.relation.ispartofjournalPharmacognosy Communications
dc.relation.ispartofvolume9
dc.subject.fieldofresearchPharmacogenomics
dc.subject.fieldofresearchPlant Biology
dc.subject.fieldofresearchPharmacology and Pharmaceutical Sciences
dc.subject.fieldofresearchcode111505
dc.subject.fieldofresearchcode0607
dc.subject.fieldofresearchcode1115
dc.titleBrachychiton rupestris (T.Mitch. ex Lindl.) K. Schum. Extracts Inhibit the Growth of Streptococcus pyogenes
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationMpala, L; Chikowe, G; Cock, IE, Brachychiton rupestris (T.Mitch. ex Lindl.) K. Schum. Extracts Inhibit the Growth of Streptococcus pyogenes, Pharmacognosy Communications, 2019, 9 (1), pp. 27-33
dcterms.licensehttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.date.updated2021-06-01T21:46:26Z
dc.description.versionVersion of Record (VoR)
gro.rights.copyright© The Author(s) 2019. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International (CC BY-NC-ND 4.0) License (http://creativecommons.org/licenses/by-nc-nd/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, providing that the work is properly cited.
gro.hasfulltextFull Text
gro.griffith.authorCock, Ian E.
gro.griffith.authorMpala, Lindiwe N.
gro.griffith.authorChikowe, Getmore R.


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