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dc.contributor.authorBryant, Krystal
dc.contributor.authorCock, Ian Edwin
dc.date.accessioned2021-06-02T01:29:02Z
dc.date.available2021-06-02T01:29:02Z
dc.date.issued2017
dc.identifier.issn2249-0159
dc.identifier.doi10.5530/pc.2017.1.3
dc.identifier.urihttp://hdl.handle.net/10072/404837
dc.description.abstractIntroduction: Eupomatia laurina are trees native to Australia and Papua New Guinea. The fruit of this species are consumed as a bushfood. Infusions and decoctions produced from leaves and bark have reputed antiseptic properties and were used traditionally to treat a variety of bacterial diseases. Despite this, E. laurina fruit solvent extractions have not been rigorously examined for antibacterial properties against many pathogens. Methods: The antimicrobial activity of E. laurina fruit solvent extractions was investigated by disc diffusion and growth time course assays against a panel of pathogenic bacteria. The growth inhibitory activity was quantified by MIC determination. Toxicity was determined using the Artemia franciscana nauplii bioassay. Results: Methanolic and aqueous E. laurina fruit extracts inhibited the growth of a wide range of bacterial species. Growth of both gram positive and gram negative bacteria was inhibited by the E. laurina fruit extracts to approximately the same extent. With some noteable exceptions, the methanolic extracts were generally more potent than the aqueous extracts. The methanolic and aqueous E. laurina fruit extracts were particularly potent inhibitors of P. mirabilis growth, with MIC values as low as 83 μg/mL (aqueous extract against the P. mirabilis clinical isolate). The antibacterial activity of the methanolic E. laurina fruit extract was further investigated by growth time course assays which showed significant growth inhibition in cultures of K. pneumoniae and P. mirabilis within 1 h of exposure. All extracts were determined to be nontoxic in the Artemia franciscana nauplii bioassay, indicating their safety for internal use as well as for topical uses. Conclusions: The lack of toxicity of the E. laurina fruit extracts and their growth inhibitory bioactivity against a panel of pathogenic bacteria partially validate the traditional usage of these species to treat bacterial diseases and indicate their potential in the development of antiseptic agents.
dc.description.peerreviewedYes
dc.publisherPharmacognosy Network Worldwide
dc.relation.ispartofpagefrom16
dc.relation.ispartofpageto23
dc.relation.ispartofissue1
dc.relation.ispartofjournalPharmacognosy Communications
dc.relation.ispartofvolume7
dc.subject.fieldofresearchPlant Biology
dc.subject.fieldofresearchPharmacology and Pharmaceutical Sciences
dc.subject.fieldofresearchcode0607
dc.subject.fieldofresearchcode1115
dc.titleEupomatia laurina R. Br. fruit solvent extractions inhibit the growth of a panel of pathogenic bacteria
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationBryant, K; Cock, IE, Eupomatia laurina R. Br. fruit solvent extractions inhibit the growth of a panel of pathogenic bacteria, Pharmacognosy Communications, 2017, 7 (1), pp. 16-23
dcterms.licensehttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.date.updated2021-06-02T00:53:27Z
dc.description.versionVersion of Record (VoR)
gro.rights.copyright© The Author(s) 2017. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International (CC BY-NC-ND 4.0) License (http://creativecommons.org/licenses/by-nc-nd/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, providing that the work is properly cited.
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gro.griffith.authorCock, Ian E.


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