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dc.contributor.authorZhang, Jiayu
dc.contributor.authorBiggs, Isaac
dc.contributor.authorSirdaarta, Joseph
dc.contributor.authorWhite, Alan
dc.contributor.authorEdwin Cock, Ian
dc.date.accessioned2021-06-02T05:23:29Z
dc.date.available2021-06-02T05:23:29Z
dc.date.issued2016
dc.identifier.issn2249-0159en_US
dc.identifier.doi10.5530/pc.2016.3.2en_US
dc.identifier.urihttp://hdl.handle.net/10072/404864
dc.description.abstractBackground: Boswellia carteri Birdw. (frankincense) and Commiphora molmol Engl. (myrrh) oleo-resins have traditionally been used for the growth inhibition of bacteria associated with skin diseases, urinary tract infections, respiratory infections, wound healing, dental disease and gastrointestinal disorders. Despite this, many bacterial pathogens are yet to be screened for susceptibility to frankincense and myrrh extracts. This study was undertaken to test extracts prepared from frankincense and myrrholeo-resins for the ability to inhibit microbial and cancer cell growth. Materials and Methods: Frankincense and myrrhresins were extracted and tested for antimicrobial activity using modified disc diffusion and MIC methods. Inhibitory activity against CaCo2 and HeLa cancer cell lines was evaluated using colorimetric cell proliferation assays. Toxicity was evaluated using an Artemia franciscana nauplii bioassay. The most promising inhibitory extracts were investigated using non-targeted GC-MS head space analysis (with screening against a compound database) for the identification and characterisation of individual components in the crude plant extracts. Results: The frankincense and myrrh extracts displayed broad spectrum antibacterial activity, inhibiting the growth of all of the bacteria screened against. The frankincense extracts were generally more potent growth inhibitors than were the corresponding myrrh extracts. The growth inhibition of the methanolic, ethyl acetate and hexane frankincense extracts against Salmonella salford was particularly noteworthy, with MIC values of 462, 258 and 293 µg/mL respectively. The frankincense and myrrh extracts were both approximately equally effective against gram positive and gram negative bacteria. The majority of the extracts also proved effective at blocking the proliferation of the colorectal cancer cell line CaCo2 and HeLa cervical cancer cell growth, although the aqueous and ethyl acetate frankincense extracts generally had the greatest efficacy (IC50 values 1600-1900 µg/mL). All extracts were non-toxic, with LC50 values substantially > 1000 µg/mL. Conclusion: These studies validate traditional usage of frankincense and myrrh in the treatment of several bacterial illnesses and some cancers, and indicate that they are safe for therapeutic usage.en_US
dc.publisherPharmacognosy Network Worldwideen_US
dc.relation.ispartofpagefrom120en_US
dc.relation.ispartofpageto136en_US
dc.relation.ispartofissue3en_US
dc.relation.ispartofjournalPharmacognosy Communicationsen_US
dc.relation.ispartofvolume6en_US
dc.subject.fieldofresearchPlant Biologyen_US
dc.subject.fieldofresearchPharmacology and Pharmaceutical Sciencesen_US
dc.subject.fieldofresearchcode0607en_US
dc.subject.fieldofresearchcode1115en_US
dc.titleAntibacterial and Anticancer Properties of Boswellia carteri Birdw. and Commiphora molmol Engl. Oleo-Resin Solvent Extractionsen_US
dc.typeJournal articleen_US
dcterms.bibliographicCitationZhang, J; Biggs, I; Sirdaarta, J; White, A; Edwin Cock, I, Antibacterial and Anticancer Properties of Boswellia carteri Birdw. and Commiphora molmol Engl. Oleo-Resin Solvent Extractions, Pharmacognosy Communications, 6 (3), pp. 120-136en_US
dcterms.licensehttps://creativecommons.org/licenses/by-nc-nd/4.0/en_US
dc.date.updated2021-06-02T01:04:00Z
dc.description.versionVersion of Record (VoR)en_US
gro.rights.copyright© The Author(s) 2016. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International (CC BY-NC-ND 4.0) License (http://creativecommons.org/licenses/by-nc-nd/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, providing that the work is properly cited.en_US
gro.hasfulltextFull Text
gro.griffith.authorCock, Ian E.


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