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dc.contributor.authorJay Lee, Cameron
dc.contributor.authorHenry Wright, Mitchell
dc.contributor.authorJean Arnold, Megan Sarah
dc.contributor.authorCarlson Greene, Anthony
dc.contributor.authorEdwin Cock, Ian
dc.date.accessioned2021-06-02T05:36:17Z
dc.date.available2021-06-02T05:36:17Z
dc.date.issued2016
dc.identifier.issn2249-0159en_US
dc.identifier.doi10.5530/pc.2016.3.6en_US
dc.identifier.urihttp://hdl.handle.net/10072/404865
dc.description.abstractIntroduction: Streptococcus pyogenes can cause a variety of diseases including streptococcal pharyngitis, impetigo and rheumatic heart disease, dependant on which tissue it infects. Many Australian plants have documented therapeutic properties as general antiseptics, but are yet to be tested for the ability to inhibit S. pyogenes growth. Methods: Solvent extracts were prepared using Australian plants with documented ethnobotanical usage to treat bacterial infections, or published antibacterial activity. The extracts were investigated by disc diffusion assay for the ability to inhibit the growth of a clinical strain of S. pyogenes. Their MIC values were determined to quantify and compare their efficacies. Toxicity was determined using the Artemia franciscana nauplii bioassay. Results: S. pyogenes growth was inhibited by 24 of the 34 extracts tested. The Eucalyptus spp. extracts were particularly potent. MIC values of 341 and 88 μg/ mL were determined for the aqueous and methanolic E. baileyana extracts respectively. Similarly, MIC values of 134 and 53 μg/mL were determined for the aqueous and methanolic E. major extracts respectively. The methanolic wattle seed extract, aqueous and methanolic lemon aspen extracts, aqueous native thyme extract, methanolic river mint extract and the methanolic native basil extract were similarly potent growth inhibitors, with MIC values ≤1000 μg/mL. Several other extracts (methanolic native tamarind, bush tomato, desert lime, native thyme, native sage and the T. stipitata leaf extracts, as well as the aqueous river mint, native basil, T. stipitata leaf extracts) displayed moderate growth inhibitory activity (MIC=1000-5000 μg/mL). All other extracts were either low potency S. pyogenes growth inhibitors or were devoid of inhibitory activity. The E. baileyana and E. major methanolic extracts, as well as the E. baileyana aqueous extract induced significant mortality in the Artemia fransiscana bioassay, with LC50 values substantially <1000 μg/mL. All other extracts were nontoxic, with LC50 values >1000 μg/mL. Conclusion: The potent growth inhibitory bioactivity of the Eucalyptus spp., lemon aspen, wattle seed, native basil and river mint extracts against S. pyogenes demonstrates their potential for the treatment and prevention of S. pyogenes induced disease. However, the toxicity of the Eucalyptus spp. extracts may limit their use to topical treatments for pharyngitis and impetigo. As the lemon aspen, wattle seed, native basil and river mint extracts were nontoxic, they may also have wider uses in treating systemic illnesses such as rheumatic fever, rheumatic heart disease and cellulitis.en_US
dc.publisherPharmacognosy Network Worldwideen_US
dc.relation.ispartofpagefrom164en_US
dc.relation.ispartofpageto173en_US
dc.relation.ispartofissue3en_US
dc.relation.ispartofjournalPharmacognosy Communicationsen_US
dc.relation.ispartofvolume6en_US
dc.subject.fieldofresearchPlant Biologyen_US
dc.subject.fieldofresearchPharmacology and Pharmaceutical Sciencesen_US
dc.subject.fieldofresearchcode0607en_US
dc.subject.fieldofresearchcode1115en_US
dc.titleInhibition of Streptococcus pyogenes growth by native Australian plants: New approaches towards the management of impetigo, pharyngitis and rheumatic heart diseaseen_US
dc.typeJournal articleen_US
dcterms.bibliographicCitationJay Lee, C; Henry Wright, M; Jean Arnold, MS; Carlson Greene, A; Edwin Cock, I, Inhibition of Streptococcus pyogenes growth by native Australian plants: New approaches towards the management of impetigo, pharyngitis and rheumatic heart disease, Pharmacognosy Communications, 6 (3), pp. 164-173en_US
dcterms.licensehttps://creativecommons.org/licenses/by-nc-nd/4.0/en_US
dc.date.updated2021-06-02T01:05:12Z
dc.description.versionVersion of Record (VoR)en_US
gro.rights.copyright© The Author(s) 2016. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International (CC BY-NC-ND 4.0) License (http://creativecommons.org/licenses/by-nc-nd/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, providing that the work is properly cited.en_US
gro.hasfulltextFull Text
gro.griffith.authorCock, Ian E.


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