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dc.contributor.authorBryant, Krystal
dc.contributor.authorCock, Ian Edwin
dc.date.accessioned2021-06-02T05:40:08Z
dc.date.available2021-06-02T05:40:08Z
dc.date.issued2016
dc.identifier.issn2249-0159
dc.identifier.doi10.5530/pc.2016.4.2
dc.identifier.urihttp://hdl.handle.net/10072/404867
dc.description.abstractIntroduction: B. myrtifolia and S. anisatum are native Australian trees with uses as traditional medicines and bushfoods. Essential oils produced from leaves of these species have reputed antiseptic properties. Despite this, B. myrtifolia and S. anisatum leaf solvent extractions have not been rigorously examined for antibacterial properties against many pathogens. Methods: The antimicrobial activity of aqueous and methanolic leaf extracts of B. myrtifolia and S. anisatum was investigated by disc diffusion and growth time course assays against a panel of pathogenic bacteria. The growth inhibitory activity was quantified by MIC determination. Toxicity was determined using the Artemia franciscana nauplii bioassay. Results: Methanolic and aqueous B. myrtifolia and S. anisatum leaf extracts inhibited the growth of a wide range of bacterial species. Growth of both gram positive and gram negative bacteria was inhibited the B. myrtifolia and S. anisatum extracts to approximately the same extent. In general, S. anisatum extracts were more potent inhibitors of bacterial growth than were the B. myrtifolia extracts, and (with some noteable exceptions) the methanolic extracts were generally more potent than the aqueous extracts. The B. myrtifolia and S. anisatum extracts were particularly potent inhibitors of P. mirabilis growth, with MIC values as low as 105 μg/mL (aqueous S. anisatum extract). The antibacterial activity of the methanolic B. myrtifolia and S. anisatum extracts were further investigated by growth time course assays which showed significant growth inhibition in cultures of E. coli, K. pneumpniae and P. mirabilis within 1 h of exposure. All extracts were determined to be nontoxic in the Artemia franciscana nauplii bioassay, indicating their safety for internal use as well as for topical uses. Conclusions: The lack of toxicity of the B. myrtifolia and S. anisatum extracts and their growth inhibitory bioactivity against a panel of pathogenic bacteria partially validate Australian Aboriginal usage of these species as antiseptic agent and indicate their potential in the development of antiseptic agents.
dc.description.peerreviewedYes
dc.publisherPharmacognosy Network Worldwide
dc.relation.ispartofpagefrom194
dc.relation.ispartofpageto203
dc.relation.ispartofissue4
dc.relation.ispartofjournalPharmacognosy Communications
dc.relation.ispartofvolume6
dc.subject.fieldofresearchPlant Biology
dc.subject.fieldofresearchPharmacology and Pharmaceutical Sciences
dc.subject.fieldofresearchcode0607
dc.subject.fieldofresearchcode1115
dc.titleGrowth inhibitory properties of Backhousia myrtifolia Hook. & Harv. and Syzygium anisatum (Vickery) Craven & Biffen extracts against a panel of pathogenic bacteria
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationBryant, K; Cock, IE, Growth inhibitory properties of Backhousia myrtifolia Hook. & Harv. and Syzygium anisatum (Vickery) Craven & Biffen extracts against a panel of pathogenic bacteria, Pharmacognosy Communications, 2016, 6 (4), pp. 194-203
dcterms.licensehttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.date.updated2021-06-02T01:06:59Z
dc.description.versionVersion of Record (VoR)
gro.rights.copyright© The Author(s) 2016. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International (CC BY-NC-ND 4.0) License (http://creativecommons.org/licenses/by-nc-nd/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, providing that the work is properly cited.
gro.hasfulltextFull Text
gro.griffith.authorCock, Ian E.


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