Cordyline rubra Otto and A. Dietr. Leaf and Fruit Extracts Lack Antibacterial Activity and are Non-toxic in vitro
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Author(s)
Mpala, Lindy
Chikowe, Getmore
Cock, Ian Edwin
Year published
2019
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Introduction: The development of bacterial strains that are resistant to multiple antibiotics has made the development of new antibiotics a priority for medical research. Traditional plant medicines are important leads for the discovery of new medicines. The family Agavaceae is widely used therapeutically in many areas of the world. Despite this, many members of this family are yet to be examined extensively for therapeutic properties. The species Cordyline rubra Otto and A. Dietr. was screened for antibacterial activity in this study. Methods: The ability of C. rubra leaf and fruit extracts to inhibit the growth of a panel ...
View more >Introduction: The development of bacterial strains that are resistant to multiple antibiotics has made the development of new antibiotics a priority for medical research. Traditional plant medicines are important leads for the discovery of new medicines. The family Agavaceae is widely used therapeutically in many areas of the world. Despite this, many members of this family are yet to be examined extensively for therapeutic properties. The species Cordyline rubra Otto and A. Dietr. was screened for antibacterial activity in this study. Methods: The ability of C. rubra leaf and fruit extracts to inhibit the growth of a panel of bacterial pathogens was investigated by disc diffusion assay. Toxicity was examined using the Artemia franciscana nauplii bioassay. Results: Methanolic C. rubra leaf and fruit extracts were completely ineffective at inhibiting the growth of gram-positive and gramnegative panels of bacteria. The extracts were also non-toxic or of low toxicity following 24 h exposure. Conclusion: C. rubra leaf and fruit extracts were completely ineffective bacterial growth inhibitors. However, these extracts may have other therapeutic properties and testing against protozoa, fungi, virus and tumour cells is required.
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View more >Introduction: The development of bacterial strains that are resistant to multiple antibiotics has made the development of new antibiotics a priority for medical research. Traditional plant medicines are important leads for the discovery of new medicines. The family Agavaceae is widely used therapeutically in many areas of the world. Despite this, many members of this family are yet to be examined extensively for therapeutic properties. The species Cordyline rubra Otto and A. Dietr. was screened for antibacterial activity in this study. Methods: The ability of C. rubra leaf and fruit extracts to inhibit the growth of a panel of bacterial pathogens was investigated by disc diffusion assay. Toxicity was examined using the Artemia franciscana nauplii bioassay. Results: Methanolic C. rubra leaf and fruit extracts were completely ineffective at inhibiting the growth of gram-positive and gramnegative panels of bacteria. The extracts were also non-toxic or of low toxicity following 24 h exposure. Conclusion: C. rubra leaf and fruit extracts were completely ineffective bacterial growth inhibitors. However, these extracts may have other therapeutic properties and testing against protozoa, fungi, virus and tumour cells is required.
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Journal Title
Pharmacognosy Communications
Volume
9
Issue
4
Copyright Statement
© The Author(s) 2019. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International (CC BY-NC-ND 4.0) License (http://creativecommons.org/licenses/by-nc-nd/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, providing that the work is properly cited.
Subject
Pharmacogenomics
Plant Biology
Pharmacology and Pharmaceutical Sciences