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  • Synthesis of New N-Arylpyrimidin-2-amine Derivatives Using a Palladium Catalyst

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    Author(s)
    El-Deeb, Ibrahim Mustafa
    Ryu, Jae Chun
    Lee, So
    Griffith University Author(s)
    El-Deeb, Ibrahim Mustafa
    Year published
    2008
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    Abstract
    New N-aryl-4-(pyridin-3-yl)pyrimidin-2-amine derivatives were synthesizedfrom the corresponding amines, applying optimized Buchwald-Hartwig aminationconditions using dichlorobis(triphenylphosphine)Pd(II), xantphos and sodium tertbutoxidein refluxing toluene under a nitrogen atmosphere. The target N-aryl derivativeswere obtained in moderate to good yields ranging from 27% to 82%. The proceduredescribed could be widely employed for the preparation of new heterocyclic compounds.The structures of the new compounds were confirmed by FT-NMR, FT-IR and elementalanalysis.New N-aryl-4-(pyridin-3-yl)pyrimidin-2-amine derivatives were synthesizedfrom the corresponding amines, applying optimized Buchwald-Hartwig aminationconditions using dichlorobis(triphenylphosphine)Pd(II), xantphos and sodium tertbutoxidein refluxing toluene under a nitrogen atmosphere. The target N-aryl derivativeswere obtained in moderate to good yields ranging from 27% to 82%. The proceduredescribed could be widely employed for the preparation of new heterocyclic compounds.The structures of the new compounds were confirmed by FT-NMR, FT-IR and elementalanalysis.
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    Journal Title
    Molecules
    Volume
    13
    Issue
    4
    DOI
    https://doi.org/10.3390/molecules13040818
    Copyright Statement
    © 2008 MDPI (http://www.mdpi.org). The attached file is reproduced here in accordance with the copyright policy of the publisher. Please refer to the journal's website for access to the definitive, published version.
    Subject
    Organic Chemical Synthesis
    Medicinal and Biomolecular Chemistry
    Organic Chemistry
    Theoretical and Computational Chemistry
    Publication URI
    http://hdl.handle.net/10072/40488
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    • Journal articles

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