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dc.contributor.authorLawson, Rachael A
dc.contributor.authorWilliams-Gray, Caroline H
dc.contributor.authorCamacho, Marta
dc.contributor.authorDuncan, Gordon W
dc.contributor.authorKhoo, Tien K
dc.contributor.authorBreen, David P
dc.contributor.authorBarker, Roger A
dc.contributor.authorRochester, Lynn
dc.contributor.authorBurn, David J
dc.contributor.authorYarnall, Alison J
dc.contributor.authorICICLE-PD study group
dc.date.accessioned2021-06-08T04:05:35Z
dc.date.available2021-06-08T04:05:35Z
dc.date.issued2021
dc.identifier.issn1877-7171
dc.identifier.doi10.3233/JPD-212581
dc.identifier.urihttp://hdl.handle.net/10072/404989
dc.description.abstractBACKGROUND: Cognitive impairment is common in Parkinson's disease (PD), with 80% cumulatively developing dementia (PDD). OBJECTIVE: We sought to identify tests that are sensitive to change over time above normal ageing so as to refine the neuropsychological tests predictive of PDD. METHODS: Participants with newly diagnosed PD (n = 211) and age-matched controls (n = 99) completed a range of clinical and neuropsychological tests as part of the ICICLE-PD study at 18-month intervals over 72 months. Impairments on tests were determined using control means (<1-2SD) and median scores. Mild cognitive impairment (PD-MCI) was classified using 1-2SD below normative values. Linear mixed effects modelling assessed cognitive decline, while Cox regression identified baseline predictors of PDD. RESULTS: At 72 months, 46 (cumulative probability 33.9%) participants had developed PDD; these participants declined at a faster rate in tests of global cognition, verbal fluency, memory and attention (p <  0.05) compared to those who remained dementia-free. Impaired baseline global cognition, visual memory and attention using median cut-offs were the best predictors of early PDD (area under the curve [AUC] = 0.88, p <  0.001) compared to control-generated cut-offs (AUC = 0.76-0.84,p <  0.001) and PD-MCI (AUC] = 0.64-0.81, p <  0.001). Impaired global cognition and semantic fluency were the most useful brief tests employable in a clinical setting (AUC = 0.79, p <  0.001). CONCLUSION: Verbal fluency, attention and memory were sensitive to change in early PDD and may be suitable tests to measure therapeutic response in future interventions. Impaired global cognition, attention and visual memory were the most accurate predictors for developing a PDD. Future studies could consider adopting these tests for patient clinical trial stratification.
dc.description.peerreviewedYes
dc.languageeng
dc.publisherIOS Press
dc.relation.ispartofjournalJournal of Parkinson's Disease
dc.subject.fieldofresearchBiochemistry and Cell Biology
dc.subject.fieldofresearchNeurosciences
dc.subject.fieldofresearchcode0601
dc.subject.fieldofresearchcode1109
dc.subject.keywordsParkinson’s disease
dc.subject.keywordscognitive dysfunction
dc.subject.keywordsneurocognitive disorders
dc.subject.keywordsneuropsychological tests
dc.titleWhich Neuropsychological Tests? Predicting Cognitive Decline and Dementia in Parkinson's Disease in the ICICLE-PD Cohort
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationLawson, RA; Williams-Gray, CH; Camacho, M; Duncan, GW; Khoo, TK; Breen, DP; Barker, RA; Rochester, L; Burn, DJ; Yarnall, AJ; ICICLE-PD study group, , Which Neuropsychological Tests? Predicting Cognitive Decline and Dementia in Parkinson's Disease in the ICICLE-PD Cohort, Journal of Parkinson's Disease, 2021
dc.date.updated2021-06-08T01:55:10Z
dc.description.versionAccepted Manuscript (AM)
gro.rights.copyright© 2021 IOS Press. This is the author-manuscript version of this paper. Reproduced in accordance with the copyright policy of the publisher. Please refer to the journal website for access to the definitive, published version.
gro.hasfulltextFull Text
gro.griffith.authorKhoo, Tien Kheng


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