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dc.contributor.authorIslam, Kamrul
dc.contributor.authorHeffernan, Aaron J
dc.contributor.authorNaicker, Saiyuri
dc.contributor.authorHenderson, Andrew
dc.contributor.authorHassen Chowdhury, Mohammed Abdul
dc.contributor.authorRoberts, Jason A
dc.contributor.authorSime, Fekade B
dc.date.accessioned2021-06-10T00:33:08Z
dc.date.available2021-06-10T00:33:08Z
dc.date.issued2021
dc.identifier.issn1746-0913
dc.identifier.doi10.2217/fmb-2020-0193
dc.identifier.urihttp://hdl.handle.net/10072/405050
dc.description.abstractAim: To determine the prevalence of extended-spectrum β-lactamase (ESBL) and metallo-β-lactamase (MBL)-producing Escherichia coli in South Asia. Methodology: A systematic review and meta-analysis of data published in PubMed, EMBASE, Web of Science and Scopus. Results: The pooled prevalence of ESBL and MBL-producing E. coli in South Asia were 33% (95% CI: 27-40%) and 17% (95% CI: 12-24%), respectively. The prevalence of bla CTX-M type was 58% (95% CI: 49-66%) with blaCTX-M-15 being the most prevalent (51%, 95% CI: 40-62%) variant. The most prevalent MBL variant was blaNDM-1 (33%, 95% CI: 20-50%). Conclusion: This study suggests a high prevalence of ESBLs and MBLs among E. coli clinical isolates. Comprehensive resistance surveillance is required to guide clinicians prescribing antibiotics in South Asia.
dc.description.peerreviewedYes
dc.languageEnglish
dc.publisherFuture Medicine
dc.relation.ispartofpagefrom521
dc.relation.ispartofpageto535
dc.relation.ispartofissue7
dc.relation.ispartofjournalFuture Microbiology
dc.relation.ispartofvolume16
dc.subject.fieldofresearchMicrobiology
dc.subject.fieldofresearchMedical microbiology
dc.subject.fieldofresearchcode3107
dc.subject.fieldofresearchcode3207
dc.subject.keywordsScience & Technology
dc.subject.keywordsLife Sciences & Biomedicine
dc.subject.keywordsEscherichia coli
dc.subject.keywordsextended-spectrum &#946
dc.titleEpidemiology of extended-spectrum β-lactamase and metallo-β-lactamase-producing Escherichia coli in South Asia
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationIslam, K; Heffernan, AJ; Naicker, S; Henderson, A; Hassen Chowdhury, MA; Roberts, JA; Sime, FB, Epidemiology of extended-spectrum β-lactamase and metallo-β-lactamase-producing Escherichia coli in South Asia, Future Microbiology, 2021, 16 (7), pp. 521-535
dc.date.updated2021-06-09T06:21:16Z
gro.hasfulltextNo Full Text
gro.griffith.authorHeffernan, Aaron J.


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